Epigenomic and Metabolomic Clues to Early and Ongoing Vascular and Heart Disease
Official title: Epigenomic and Metabolomics Determinants of Subclinical and Clinical Vascular and Myocardial Disease
Funded at Emory University · NIH-11323896 · Data updated 2026-11-12
This grant supports a multi-omic study at Emory to find molecular clues in blood and tissues that predict and explain early and clinical vascular disease and heart failure, especially in South Asians.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | May 15, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $272,504 |
| NIH project number | 5P01HL154996-05 |
| Project ID | NIH-11323896 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults at risk for or living with ASCVD and heart failure, with emphasis on populations underrepresented in current research, such as South Asians.
✕Less likely to help
Individuals without cardiovascular risk factors or disease are unlikely to directly benefit from this research.
What this research studies
Researchers will perform untargeted analyses of epigenetic marks and metabolites to identify molecular patterns linked to subclinical and clinical cardiovascular disease, including ASCVD and various forms of heart failure. The study will explore how genetic and environmental factors interact to influence disease risk and progression, aiming to improve early detection and prevention strategies. The work focuses on diverse populations and seeks to uncover new biological pathways that could become targets for therapy or risk prediction.
Why it matters
Potential benefit: If successful, the project could lead to more precise risk prediction and earlier intervention for people at risk of ASCVD and heart failure, potentially reducing heart-related events.
How similar studies have gone: Previous multi-omic approaches have shown promise in identifying novel pathways, though applying them to ASCVD/HF in diverse populations remains an area of active exploration.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Sun, Yan — Emory University
- Study coordinator: Sun, Yan
Related research
Other NIH-funded projects on the same topics.
-
Newborn screening: using gene and metabolite data to refine true vs false positives
A study using genetic and metabolomic data from newborn blood spots to better distinguish real metabolic disorders from false alarms.
-
IDEAL: How early-life immune development shapes vaccine responses and asthma risk
A child-focused project that looks at how the developing immune system in early life affects vaccine responses, respiratory infections, and asthma.
-
Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
-
Metabolomics clues to how ultra-processed foods affect risk of type 2 diabetes
A scientist-led study will look at how eating different ultra-processed foods may change diabetes risk by using a controlled feeding trial and big population data, focusing on adults.
-
Longitudinal metabolomics in infants with food allergies
A study in infants aims to understand how gut metabolites relate to the development of food allergies, including IgE-mediated and non-IgE cases.
-
Biospecimen, Metabolomics, and Pathology Core for Endometrial Cancer Research
A national, multi-institutional resource collects and analyzes tissue, blood, and metabolites from endometrial cancer patients to support multiple research projects.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.