Condition

Kidney Transplantation clinical trials and research

• 29Clinical trials
• 75NIH research projects
• 1New in 30 days
• 14Countries

Newest Kidney Transplantation clinical trials

All recruiting trials (29)

• Italian Registry of Pediatric Dialysis: collecting data from kids on kidney replacement therapy

  This registry in Italy tests how collecting epidemiological, clinical, and treatment data from children on dialysis or pre-emptive kidney transplants can help centers share protocols and improve care.

  Recruiting at 12 sites Istituto Giannina Gaslini · Ancona and 11 other locations · NCT07918066

• Intraoperative diuretics during deceased-donor kidney transplants

  This trial tests whether using furosemide or mannitol during kidney transplant surgery affects delayed graft function in adults receiving a deceased-donor kidney.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario and 1 other locations · NCT07726134

• Immune Reset to Enable Kidney Transplant for Highly Sensitized Patients

  This study tests whether a temporary immune system reboot using a patient’s own stem cells can help highly sensitized kidney patients receive a compatible transplant.

  Recruiting Phase 1/2 Hospital Universitari Vall d'Hebron Research Institute · Barcelona, Catalonia · NCT07607197

• Home-based exercise to boost fitness for people waiting for a kidney transplant

  This study tests whether a 12-week, home-based exercise program plus a wearable activity tracker helps adults on the kidney transplant waiting list increase daily activity and improve physical function.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07446296

• A six-week online self-management program for adults in Israel with chronic conditions

  This six-week online group program will try to help adults in Israel who have chronic conditions—such as cancer survivors or kidney transplant recipients—learn practical skills to manage symptoms and daily health.

  Recruiting University of Haifa · Tel Aviv · NCT07367750

• Vonoprazan to reduce delayed graft function after deceased-donor kidney transplant

  This trial will test whether giving vonoprazan around the time of surgery lowers the chance of delayed graft function in adults receiving their first deceased-donor kidney transplant.

  Recruiting Phase 1/2 First Affiliated Hospital of Chongqing Medical University · Chongqing and 1 other locations · NCT07275632

• GGTA1 KO pig kidney with thymus for people with end-stage kidney failure

  This test tries a genetically modified pig kidney with attached thymus tissue (GGTA1 KO Thymokidney) in people with end-stage kidney failure who either can't get a human donor kidney or are unlikely to get one within five years.

  Recruiting Phase 1/2 United Therapeutics · New York, New York · NCT07224763

• Prehabilitation program for kidney transplant candidates

  This study is testing if using wearable sensors during exercise can help kidney transplant candidates get stronger and better prepared for their surgery.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06886256

• 10 GE Xenokidney transplant for people with end-stage kidney disease

  This program will test whether a genetically engineered pig kidney (the 10 GE Xenokidney) can safely replace failed kidneys and help adults with end-stage renal disease who are either ineligible for or unlikely to receive a human transplant.

  Recruiting at 2 sites Phase 1/2 United Therapeutics · Chicago, Illinois and 1 other locations · NCT06878560

• TTV-guided long-term immunosuppression in kidney transplant recipients

  This trial tests whether checking Torque Teno Virus (TTV) levels every three months starting in the second year after transplant can help tailor immunosuppressive drugs for adult kidney transplant recipients to reduce infections, rejection, and cancer.

  Recruiting at 2 sites Hospices Civils de Lyon · Bordeaux (France) and 3 other locations · NCT06829719

• Dipyridamole to prevent low phosphate after kidney transplant

  This study tests whether giving dipyridamole can help keep phosphate levels higher after a kidney transplant and reduce the need for phosphate supplements.

  Recruiting Phase 2 Stanford University · Stanford, California · NCT06824454

• Identifying biomarkers in kidney disease before and after transplantation

  This study is trying to find specific markers in urine, blood, and tissue that can help doctors better diagnose and predict kidney disease before and after a transplant.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil · NCT06810258

• Autologous expanded regulatory CD8+ T cell therapy for living-donor kidney transplant recipients

  This trial will test whether infusing a patient's own expanded regulatory CD8+ T cells (Eight Treg) around a living-donor kidney transplant can help the graft survive better and lower the need for standard immunosuppressive drugs.

  Recruiting Phase 1 Nantes University Hospital · Nantes · NCT06777719

• Monitoring glucose levels after kidney transplantation

  This study looks at how glucose levels change in kidney transplant patients during the first two weeks after surgery to see if there are differences between those with diabetes, prediabetes, and no diabetes.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen, DK · NCT06675903

• Evaluating the BETY-BQ Questionnaire for Chronic Kidney Disease and Transplant Patients

  This study is testing a new questionnaire to see how well it helps understand the challenges faced by people with chronic kidney disease, those on dialysis, and kidney transplant patients.

  Recruiting Hacettepe University · Ankara, Altındağ · NCT06591702

• Reduced immunosuppression for older kidney transplant recipients with TruGraf/TRAC monitoring

  This study will see if stopping mycophenolate mofetil (MMF) in kidney transplant patients aged 55 and older, while using TruGraf/TRAC blood tests to watch for rejection and infections, is as safe as continuing the medication.

  Recruiting at 3 sites Phase 4 Mayo Clinic · Phoenix, Arizona and 2 other locations · NCT06568549

• Regulatory T-cell therapy to reduce immunosuppression after a living-donor kidney transplant

  This trial will test whether a single infusion of a patient's expanded regulatory T cells (TRK-001) after a living-donor kidney transplant lets people safely reduce their long-term anti-rejection medications.

  Recruiting at 6 sites Phase 2 Singulera Therapeutics Inc. · Phoenix, Arizona and 6 other locations · NCT06552169

• Stopping calcineurin inhibitors in kidney transplant recipients with no HLA-DQ mismatch

  This study is testing if kidney transplant patients with a good match can safely stop taking calcineurin inhibitors while adjusting their other medications to see how it affects their kidney health.

  Recruiting Phase 4 University Hospital, Antwerp · Edegem, Antwerp · NCT06493526

• Home-based exercise program for kidney transplant recipients

  This study is testing whether a home-based exercise program can help kidney transplant recipients improve their fitness and overall health compared to different levels of exercise intensity.

  Recruiting at 2 sites KU Leuven · Ghent and 1 other locations · NCT06260579

• Using advanced MRI to assess kidney health in donors, recipients, and healthy individuals

  This study is testing if advanced MRI scans can help check kidney health in living kidney donors, transplant recipients, and healthy people without needing a biopsy.

  Recruiting at 2 sites Aalborg University Hospital · Aarhus, Central Jutland and 1 other locations · NCT06210555

• Ultrasound renal denervation for uncontrolled high blood pressure after kidney transplant

  This study will try ultrasound renal denervation on the native kidneys to see if it lowers blood pressure in kidney transplant patients whose hypertension is not controlled by medicines.

  Recruiting Erasmus Medical Center · Rotterdam · NCT05934383

• Endoscopic sleeve gastroplasty for obese kidney transplant candidates

  This study is testing if a procedure called endoscopic sleeve gastroplasty can help obese patients with kidney disease lose enough weight to qualify for a kidney transplant.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome · NCT05917795

• Using modified immune cells in living donor kidney transplantation

  This study is testing a new treatment using modified immune cells to see if it helps people who are getting a kidney transplant from a living donor.

  Recruiting at 6 sites Phase 2 TolerogenixX GmbH · Berlin and 7 other locations · NCT05365672

• Using warm perfusion to improve kidney transplantation outcomes

  This study is testing a new device that keeps kidneys warm and healthy before transplanting them to see if it helps improve the success of kidney transplants from deceased donors.

  Recruiting Ebers Medical Technology, S.L. · Zaragoza, Zaragoza · NCT05175885

• Assessing kidney blood flow changes after closing a fistula in transplant patients

  This study is testing how closing a fistula affects blood flow in the kidneys of kidney transplant patients to see if it impacts their kidney function.

  Recruiting University of Zurich · Zurich · NCT05015231

• Extracorporeal phototherapy effects on T-follicular helper and B cells in chronic antibody-mediated kidney transplant rejection

  This tests whether extracorporeal phototherapy (ECP) can change T-follicular helper and circulating B cells in adults with chronic antibody-mediated rejection after a kidney transplant.

  Recruiting at 4 sites University Hospital, Angers · Besançon and 3 other locations · NCT04870437

• Preventing incisional hernias after kidney transplantation

  This study is testing if using a special mesh during kidney transplant surgery can help prevent hernias from forming afterward in patients receiving their first transplant.

  Recruiting Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · Madrid · NCT04794582

• Evaluating the Shingrix vaccine in kidney transplant recipients

  This study tests how well the Shingrix vaccine works and its safety for people waiting for a kidney transplant.

  Recruiting at 4 sites Phase 3 University of Colorado, Denver · Aurora, Colorado and 3 other locations · NCT04128189

• Database for kidney transplantation research

  This study is creating a large database to collect information on kidney transplant patients to help researchers understand their long-term health and improve treatment options.

  Recruiting at 8 sites Nantes University Hospital · Lyon and 7 other locations · NCT02900040

NIH-funded research (newest 40 of 75)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Strategies for HIV-to-HIV kidney transplants to increase organ donations

  This project looks at making HIV-to-HIV kidney transplantation more common to help people with HIV get transplants faster by boosting organ donation and changing practice.

  NIH research University of Tennessee Knoxville · Knoxville, United States · NIH-11599369

• Biomarker-guided Immunosuppression in Kidney Transplant Patients

  A multicenter study in kidney transplant recipients is testing whether a biomarker score from HLA-DR/DQ can guide changes in immunosuppression to reduce rejection risk and drug toxicity.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11550940

• Helping the immune system accept a donated kidney in patients without prior sensitization

  This project will try giving specially treated donor B cells alongside immune-sparing medicines to teach the immune systems of kidney transplant patients without prior antibodies to accept the new kidney.

  NIH research Duke University · Durham, United States · NIH-11528916

• Lowering donor-specific antibodies in sensitized kidney transplant patients

  This project works to reduce harmful donor-specific antibodies in people who are sensitized and need a kidney transplant so their new organ lasts longer.

  NIH research Duke University · Durham, United States · NIH-11528915

• Reducing geographic disparities in kidney transplant access with AI and operations research

  Aiming to use AI and operations research to make kidney transplant access more fair across different regions in the U.S.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11433837

• Centralized patient coaching to boost live donor kidney transplantation

  A US-wide program trains patients, caregivers, and their networks with coaching to help them pursue living donor kidney transplantation.

  NIH research New York University School of Medicine · New York, United States · NIH-11433286

• Missed Pediatric Priority in Kidney Transplantation

  This research aims to improve outcomes for children with kidney disease by focusing on when and how kidney transplantation can best help young patients.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11430113

• RaDIANT Health Systems Intervention to Improve Kidney Transplant Access

  This project aims to help adults with kidney failure in the Southeastern US get faster, better access to kidney transplant through coordinated education and system-wide changes.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11416708

• Biomarker-guided changes in kidney transplant immunosuppression

  This project tests whether a biomarker score from donor and recipient immune markers can guide safer, personalized immunosuppression after kidney transplant.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11406938

• Patient-provider conversations and unequal access to home dialysis and kidney transplant

  This project explores how conversations between doctors and patients affect why some Black and Hispanic people with kidney disease don’t get home dialysis or preemptive kidney transplants as often as White or Asian patients.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11406134

• Innate immune sensing and genetic links to kidney transplant outcomes

  This grant looks at how innate immune receptors and genetic variations relate to long-term kidney transplant success in diverse patients.

  NIH research Stanford University · Stanford, United States · NIH-11401445

• APOL1 Long-term Kidney Transplant Outcomes Network Center

  This grant supports long-term follow-up and data collection from African American donors and transplant recipients to better understand how APOL1 gene variants affect kidney transplant outcomes.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11393614

• A tool to help decide kidney transplants for people who had cancer

  A patient-friendly tool will help doctors and patients understand how kidney transplant may affect survival for people with end-stage kidney disease who have a history of cancer.

  NIH research Hennepin Healthcare Research Institute · Minneapolis, United States · NIH-11381076

• Monocyte and Macrophage Roles in Kidney Transplant Health

  This study looks at how monocytes and macrophages behave after kidney transplant to find ways to reduce rejection and long-term damage.

  NIH research Duke University · Durham, United States · NIH-11378466

• APOL1 Genetics and Kidney Transplant Outcomes in African Ancestry Donors and Recipients

  This grant studies how donor APOL1 gene variants affect kidney transplant success, especially for recipients with African ancestry.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11375086

• Preventing weight gain and blood sugar problems after kidney transplant

  This project offers a diet and activity program for people who have had a kidney transplant to help prevent weight gain and problems with blood sugar.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11374419

• APOL1 and Long-term Kidney Transplant Outcomes Network (APOLLO) Clinical Center

  This grant supports a clinical center that studies how APOL1 gene variants and other factors affect kidney transplant survival in African American donors and recipients.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11373095

• APOLLO: Understanding APOL1 and Kidney Transplant Outcomes in African American Patients

  This project studies how APOL1 genetic variants in African American donors and recipients affect kidney transplant survival and donor health.

  NIH research Emory University · Atlanta, United States · NIH-11373092

• APOL1 Kidney Transplantation Outcomes Network Clinical Center

  A clinical center part of a nationwide effort to study APOL1 gene effects on long-term kidney transplant success.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11373078

• APOLLO: Understanding APOL1 in Black Americans and Kidney Transplants

  This project looks at how APOL1 gene variants affect kidney disease risk and transplant outcomes in Black Americans.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11372937

• ApoL1 Kidney Transplant Outcomes Network study at Johns Hopkins

  This project studies how APOL1 gene variants affect kidney transplant results, especially for recipients from donors with African ancestry.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11372923

• APOLLO: Long-term Kidney Transplant Outcomes in African Ancestry

  A national network study is following kidney transplant patients and living donors with African ancestry to understand how APOL1 gene variants affect transplant success and kidney function.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11372897

• APOL1 Kidney Transplant Network Clinical Center

  This grant supports a national effort to study how APOL1 gene variants affect kidney transplant outcomes, especially in African American donors and recipients.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11372875

• APOL1 and Kidney Transplant Outcomes in African American Donors and Recipients

  This program studies how APOL1 gene variants in African American kidney donors and recipients affect long-term transplant success and kidney health after donation.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11372853

• APOL1-Linked Kidney Transplant Outcomes Network (APOLLO) Clinical Center

  This grant supports a clinical center that follows kidney transplant patients to understand how APOL1 genetics affect transplant results and living donor health.

  NIH research Joslin Diabetes Center · Boston, United States · NIH-11372324

• Racial disparities in access to kidney transplantation

  This grant looks at why Black and Hispanic adults have less access to kidney transplantation and how doctors’ communication and clinic interactions may shape those differences.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11362000

• Autologous CAR-T therapy to reduce anti-HLA antibodies before kidney transplant

  A patient-facing trial tests a personalized CAR-T cell therapy to lower harmful antibodies that block kidney transplantation in people with end-stage kidney disease.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11352525

• Gut microbes and blood chemicals linked to pain after kidney transplant

  This project looks at how changes in gut bacteria and blood metabolites relate to chronic pain in adults after a kidney transplant.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11336389

• Eplet mismatch analysis to improve pediatric kidney transplants

  A pediatric kidney transplant research effort is testing whether checking small protein differences (eplets) between donor and recipient can reduce harmful antibodies and improve long-term transplant success.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11332261

• Kidney transplants from HIV-positive donors: impact on rejection and long-term outcomes

  This study will compare kidney transplant outcomes for HIV-positive donor to HIV-positive recipient transplants versus HIV-negative donor transplants in people living with HIV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11324988

• Preventing hepatitis C after receiving a kidney from an HCV-positive donor

  This compares two ways of giving hepatitis C antivirals to people getting a kidney from an HCV-positive donor to find which best prevents infection and complications.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11319833

• Promoting Kidney Transplant Acceptance with New Immune Therapies

  A large NIH-supported effort at the University of Minnesota is testing new immune-based therapies to help kidney transplant patients avoid lifelong strong immunosuppression.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11311946

• How long the shingles (zoster) vaccine protects people with kidney failure, before and after transplant

  This project checks how long the shingles vaccine protects adults with end-stage kidney disease who are waiting for or have received a kidney transplant.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11285305

• How payment incentives affect access to home dialysis and kidney transplant

  This project looks at whether changing how dialysis centers are paid helps more patients—especially Black, Hispanic, Native American, and low-income people—get home dialysis or kidney transplants.

  NIH research Brown University · Providence, United States · NIH-11242046

• How immune cells change after a kidney transplant

  Researchers are testing ways to block specific immune cell signals to help transplanted kidneys last longer for people who receive kidney transplants.

  NIH research Duke University · Durham, United States · NIH-11187001

• Kidney transplant decisions for people who've had cancer

  This project will build a tool to help people with kidney failure who had cancer understand whether a transplant might help them live longer than staying on dialysis.

  NIH research Hennepin Healthcare Research Institute · Minneapolis, United States · NIH-11182525

• C1 esterase inhibitor injected into deceased-donor kidneys before transplant

  This trial tests whether injecting a medicine called C1 esterase inhibitor into donated deceased kidneys before transplant helps adult recipients recover better and have stronger kidney function.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11180440

• Understanding the APOL1 Gene in Kidney Transplants

  This project looks at how a gene called APOL1 affects kidney transplant success and the health of African American living kidney donors.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11145166

• Understanding Kidney Transplant Outcomes for Patients of African Ancestry

  This research helps us understand why some kidney transplants from donors of African ancestry might not last as long, so we can improve outcomes for patients.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11143752

• Understanding Kidney Transplant Outcomes for People with APOL1 Gene Variations

  This project looks at how a specific gene, APOL1, affects the success of kidney transplants, particularly for African Americans, to help improve long-term outcomes for patients.

  NIH research Joslin Diabetes Center · Boston, United States · NIH-11143630

Related topics

Quick answers

How many Kidney Transplantation clinical trials are recruiting right now?

29, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (8 trials), France (5 trials), Spain (3 trials), Belgium (2 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 4, Phase 2: 3, Phase 4: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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