Using advanced MRI to assess kidney health in donors, recipients, and healthy individuals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the use of multiparametric MRI (mpMRI) to evaluate renal fibrosis and function in living kidney donors, transplant recipients, and healthy controls. By employing various MRI techniques, the study seeks to provide a non-invasive alternative to renal biopsies, which are currently the gold standard for assessing kidney fibrosis. Participants will undergo MRI scans to measure different biophysical properties of kidney tissue, potentially leading to better monitoring of renal health and outcomes. The study will include a prospective cohort to gather comprehensive data on kidney function and fibrosis over time.

Why it matters

Who can join: the full rules

Living kidney donors and transplant recipients:

Inclusion Criteria:

* Approved as a living kidney donor or recipient of a kidney from a living donor.
* Able to cooperate to an MRI examination

Exclusion Criteria:

* Contraindications to MRI due to incompatible foreign objects.
* Severe claustrophobia

Healthy controls:

Inclusion Criteria:

* Office BP \< 140/90 mmHg. (use of 1 antihypertensive drug allowed)
* Normal eGFR. (CKD-EPI)
* Urine albumin-to-creatinine ratio \< 30 mg/g.
* Dipstick negative for hematuria and proteinuria.
* Able to cooperate to an MRI examination.

Exclusion Criteria:

* Contraindications to MRI due to incompatible foreign objects.
* Severe claustrophobia.
* Pregnancy.
* Condition(s) that would exclude living kidney donation.

Where it's running

• Department of Renal Medicine, Aarhus University Hospital
  Aarhus, Central Jutland, Denmark Recruiting
• Department of Nephrology, Aalborg University Hospital
  Aalborg, North Denmark, Denmark Recruiting

Study contacts

• Principal investigator: Patrick Schjelderup, MD — Aalborg University Hospital
• Study coordinator: Patrick Schjelderup, MD
• Email: pasc@rn.dk
• Phone: +4522212589

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.