APOL1 Kidney Transplantation Outcomes Network Clinical Center
Official title: 7/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11373078 · Data updated 2026-11-12
A clinical center part of a nationwide effort to study APOL1 gene effects on long-term kidney transplant success.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 25, 2017 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $199,879 |
| NIH project number | 5U01DK116097-09 |
| Project ID | NIH-11373078 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have received a kidney transplant or are potential living donors enrolled at participating centers.
✕Less likely to help
Individuals not contributing data or samples, or those not undergoing kidney transplantation or donation at participating sites, may not receive direct benefits.
What this research studies
This grant supports a clinical center that collaborates with multiple transplant sites to enroll kidney transplant recipients and living donors and to study how APOL1 gene variants may influence graft survival. The center works with organ procurement organizations to collect data and DNA samples, linking genetic information with transplant outcomes. The goal is to understand whether APOL1 mutations affect long-term transplant success so clinicians can improve donor selection and patient care. Participation involves patients who have had kidney transplants or who are potential living donors, through consented follow-up and data collection over several years.
Why it matters
Potential benefit: This research could improve understanding of genetic risk factors for kidney graft loss and inform donor-recipient matching and post-transplant management.
How similar studies have gone: APOLLO has previously enrolled hundreds of recipients and donors with high DNA sample availability, indicating feasibility for large observational studies.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Poggio, Emilio Daniel — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Poggio, Emilio Daniel
Related research
Other NIH-funded projects on the same topics.
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-
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-
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-
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Reducing geographic disparities in kidney transplant access with AI and operations research
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-
Centralized patient coaching to boost live donor kidney transplantation
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.