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Clinical trial Recruiting at 1 site Observational Ages 18 and up

Assessing kidney blood flow changes after closing a fistula in transplant patients

Official title: Multiparametric MRI for Assessment of Changes of Renal Hemodynamics After Fistula Closure in Kidney Transplant Patients: a Pilot Study

Run by University of Zurich · NCT05015231 · Data updated 2026-11-12

This study is testing how closing a fistula affects blood flow in the kidneys of kidney transplant patients to see if it impacts their kidney function.

More Kidney Transplantation trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment30 (estimated)
SponsorUniversity of Zurich
Academic / other
Locations1 site (Zurich)
StatusRecruiting
StartedAugust 1, 2021
Main results expectedDecember 31, 2027
Study endsDecember 31, 2027
Registry record updatedAugust 20, 2021
Trial IDNCT05015231 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are kidney transplant patients over 18 years old, with stable kidney function and planning to close their fistula.

Probably not a fit

Patients who have undergone kidney transplantation within the last 12 months or have significant kidney issues such as high proteinuria or recent rejection episodes may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates how renal hemodynamics change following the closure of arteriovenous fistulas (AVF) in kidney transplant patients using multiparametric MRI. Patients over 18 years old, who are planning to undergo surgical fistula closure and meet specific kidney function criteria, will be monitored for changes in kidney blood flow. The study aims to provide insights into the impact of fistula closure on kidney function post-transplantation. Echocardiography and MRI will be utilized as part of the assessment process.

Why it matters

Potential benefit: If successful, this study could enhance understanding of kidney function management in transplant patients after fistula closure.

How similar studies have gone: While similar studies assessing renal hemodynamics have been conducted, this specific approach using multiparametric MRI in the context of fistula closure is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Written informed consent
* Age \> 18 years
* Patients wishing to close the fistula and planned for surgical fistula closure
* eGFR CKD EPI ≥ 45 ml/min/1.73m2 at one year post transplantation
* Stable eGFR within the past 6 months
* Controlled blood pressure

Exclusion Criteria:

* Kidney Transplantation \< 12 months before fistula closure
* Proteinuria \> 500mg/d
* Presence of donor specific antibodies
* Rejection within the past 6 months
* BK virus replication within the past 3 months
* Cardiac pacemaker, which is not compatible with MRI
* Claustrophobia

Where it's running

  • University Hospital Zurich
    Zurich, Switzerland     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.