Understanding Kidney Transplant Outcomes for Patients of African Ancestry
1/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
This research helps us understand why some kidney transplants from donors of African ancestry might not last as long, so we can improve outcomes for patients.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11143752 on NIH RePORTER |
What this research studies
We know that kidney transplants from deceased donors of African American background, especially those with certain APOL1 gene types, sometimes don't last as long. However, some patients do very well with these kidneys. This project aims to discover why these differences occur by looking at how APOL1 genes interact with other factors in the body and environment. We are also looking at living donors of recent African ancestry to understand their risks after donation. Our goal is to gather long-term information on kidney function and survival to better understand these genetic and environmental influences.
Who could benefit from this research
Good fit: Patients who have received a kidney transplant, especially those from African American donors, or living kidney donors of recent African ancestry, are relevant to this research.
Not a fit: Patients receiving kidney transplants from European-American donors without the specific APOL1 high-risk genotypes may not directly benefit from this particular genetic focus.
Why it matters
Potential benefit: If successful, this work could lead to better ways to match donors and recipients, or new treatments to help kidney transplants last longer for patients of African ancestry.
How similar studies have performed: This project is part of an established NIH consortium (APOLLO) that has been collecting data since 2017, building upon existing knowledge in the field of kidney transplantation genetics.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Astor, Brad C — University of Wisconsin-Madison
- Study coordinator: Astor, Brad C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.