APOL1-Linked Kidney Transplant Outcomes Network (APOLLO) Clinical Center
Official title: 9/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
Funded at Joslin Diabetes Center · NIH-11372324 · Data updated 2026-11-12
This grant supports a clinical center that follows kidney transplant patients to understand how APOL1 genetics affect transplant results and living donor health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 25, 2017 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $217,381 |
| NIH project number | 5U01DK116102-08 |
| Project ID | NIH-11372324 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have received kidneys or are living kidney donors participating in APOLLO or similar transplant programs.
✕Less likely to help
Patients not involved in APOLLO or not carrying APOL1 risk variants may see limited or indirect benefits.
What this research studies
This project continues a multi-center effort to collect long-term data on kidney transplant recipients and living donors, focusing on how APOL1 gene variants influence outcomes like kidney function decline, rejection, and allograft survival. It builds on an established network with a track record of enrolling participants, obtaining DNA samples, and coordinating with transplant programs to improve ongoing care. The center will maintain follow-up and data collection to identify strategies that extend graft function and patient well-being. Clinicians, researchers, and participants collaborate to translate genetic insights into better donor selection and post-transplant management.
Why it matters
Potential benefit: If successful, findings could reduce organ discard, expand donor options, and improve long-term transplant success for African American patients.
How similar studies have gone: Prior APOLLO work has demonstrated feasibility and enrollment success across multiple centers, with meaningful data gathered on APOL1-related outcomes.
Where this research is happening
-
Joslin Diabetes Center
Boston, United States Active
Researchers
- Principal investigator: Rosas, Sylvia E — Joslin Diabetes Center
- Study coordinator: Rosas, Sylvia E
Related research
Other NIH-funded projects on the same topics.
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-
Centralized patient coaching to boost live donor kidney transplantation
A US-wide program trains patients, caregivers, and their networks with coaching to help them pursue living donor kidney transplantation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.