APOL1 Genetics and Kidney Transplant Outcomes in African Ancestry Donors and Recipients
Official title: 1/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
Funded at University of Wisconsin-Madison · NIH-11375086 · Data updated 2026-11-12
This grant studies how donor APOL1 gene variants affect kidney transplant success, especially for recipients with African ancestry.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 25, 2017 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $48,049 |
| NIH project number | 5U01DK116092-09 |
| Project ID | NIH-11375086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Recipients of kidney transplants or potential living kidney donors who are of recent African ancestry or have African heritage.
✕Less likely to help
Patients receiving non-African ancestry kidneys with typical outcomes may not see personalized changes from this research.
What this research studies
If a kidney comes from an African-American donor, outcomes can be worse than those from European-American donors. The project follows transplant recipients and living donors over time to see how APOL1 gene variants might interact with other factors to influence graft survival. It involves collecting long-term data on graft function, injury, and survival, and includes several clinical centers coordinated by a national consortium. Patients could contribute by joining the registry, providing samples, or consenting to long-term follow-up.
Why it matters
Potential benefit: Better understanding of genetic factors that influence transplant success could lead to personalized donor-recipient matching and improved long-term outcomes for patients.
How similar studies have gone: Prior work shows APOL1 variants are associated with transplant outcomes, with some centers reporting variable survival depending on genotype.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Astor, Brad C — University of Wisconsin-Madison
- Study coordinator: Astor, Brad C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.