Kidney transplants from HIV-positive donors: impact on rejection and long-term outcomes

Who could benefit from this research

What this research studies

If you have HIV and need a kidney transplant, this project will follow two groups across multiple centers to see how the donor's HIV status affects rejection and long-term results. Researchers will collect data from hundreds of transplants, including prior HOPE cohorts, to understand immune and infection-related factors that may drive rejection. The goal is to identify which patients benefit most, refine eligibility and monitoring, and improve immunosuppressive strategies to keep transplants lasting longer. Participation would involve standard follow-up visits and testing as part of the transplant care plan. Findings could guide safer donor selection and personalized care for HIV-positive transplant recipients.

Why it matters

Where this research is happening

• Johns Hopkins University
  Baltimore, United States Active

Researchers

• Principal investigator: Durand, Christine Marie — Johns Hopkins University
• Study coordinator: Durand, Christine Marie

Related research

Other NIH-funded projects on the same topics.

• Kidney transplantation from HIV-positive donors to HIV-positive recipients

  This study is looking at how well kidney transplants from HIV-positive donors work for people who also have HIV, to see if they have better or worse outcomes compared to transplants from HIV-negative donors, all to help improve care for patients like you.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11082518

• Strategies for HIV-to-HIV kidney transplants to increase organ donations

  This project looks at making HIV-to-HIV kidney transplantation more common to help people with HIV get transplants faster by boosting organ donation and changing practice.

  NIH research University of Tennessee Knoxville · Knoxville, United States · NIH-11599369

• Biomarker-guided Immunosuppression in Kidney Transplant Patients

  A multicenter study in kidney transplant recipients is testing whether a biomarker score from HLA-DR/DQ can guide changes in immunosuppression to reduce rejection risk and drug toxicity.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11550940

• Helping the immune system accept a donated kidney in patients without prior sensitization

  This project will try giving specially treated donor B cells alongside immune-sparing medicines to teach the immune systems of kidney transplant patients without prior antibodies to accept the new kidney.

  NIH research Duke University · Durham, United States · NIH-11528916

• Lowering donor-specific antibodies in sensitized kidney transplant patients

  This project works to reduce harmful donor-specific antibodies in people who are sensitized and need a kidney transplant so their new organ lasts longer.

  NIH research Duke University · Durham, United States · NIH-11528915

• Injecting immune-boosting medicine into melanoma tumors to help the immune system reject them

  This gives an immune-boosting drug directly into melanoma tumors in pet dogs to help their T cells find and destroy the cancer.

  NIH research Wm S. Middleton Memorial Veterans Hosp · Madison, United States · NIH-11520231

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.