Kidney transplant decisions for people who've had cancer
A clinical decision support tool to understand the survival benefit of kidney transplantation in candidates with a history of cancer
This project will build a tool to help people with kidney failure who had cancer understand whether a transplant might help them live longer than staying on dialysis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hennepin Healthcare Research Institute NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11182525 on NIH RePORTER |
What this research studies
If you have end-stage kidney disease and a history of cancer, this project aims to give you clearer information about the risks and benefits of getting a kidney transplant versus remaining on dialysis. The team will combine patient records and transplant data to estimate chances of survival and cancer returning after transplant. They will use those estimates to make a decision-support tool clinicians can use when discussing transplant listing and timing with you. The goal is to reduce uncertainty so you and your care team can make more personalized choices.
Who could benefit from this research
Good fit: Adults with end-stage kidney disease who have a prior history of cancer, especially those in remission and being considered for transplant listing, are the intended candidates.
Not a fit: People with active, untreated cancer or those who are not transplant candidates for other medical reasons are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this could help patients with prior cancer get more personalized transplant recommendations and potentially improve survival by identifying who benefits most from transplantation.
How similar studies have performed: Existing guidance is mostly based on expert opinion and small studies, so this more data-driven decision-support approach is relatively novel though it builds on prior registry research.
Where this research is happening
Minneapolis, United States
- Hennepin Healthcare Research Institute — Minneapolis, United States (Active)
Researchers
- Principal investigator: Hart, Allyson — Hennepin Healthcare Research Institute
- Study coordinator: Hart, Allyson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.