APOL1 Long-term Kidney Transplant Outcomes Network Center
Official title: 5/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
Funded at Columbia University Health Sciences · NIH-11393614 · Data updated 2026-11-12
This grant supports long-term follow-up and data collection from African American donors and transplant recipients to better understand how APOL1 gene variants affect kidney transplant outcomes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 25, 2017 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $171,116 |
| NIH project number | 5U01DK116066-09 |
| Project ID | NIH-11393614 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are African American or Black Hispanic individuals considering kidney donation or who are already enrolled as APOLLO Phase 1 participants, plus transplant recipients in the APOLLO network.
✕Less likely to help
Patients not involved in kidney donation or transplantation or those outside the APOLLO clinical center network may see limited direct benefit.
What this research studies
A network of transplant centers will track patients and donors over many years to collect detailed clinical data, biospecimens, and genetic information related to APOL1. The study will enroll new African American living kidney donors and follow existing APOLLO Phase 1 participants to identify factors that influence transplant success. Researchers will work with UNOS and other programs to assemble a rich dataset, including urine, blood, biopsy slides, and genetic results, and will return APOL1 genotype information to participants who want it. The ultimate goal is to determine how APOL1 risk variants impact donor and recipient outcomes and to build a deeply characterized cohort for future research.
Why it matters
Potential benefit: If successful, this work could clarify APOL1-related risks in kidney transplantation and improve donor and recipient counseling and long-term care.
How similar studies have gone: Previous APOLLO work has laid groundwork showing the value of long-term follow-up; this phase expands data depth and diversity.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Mohan, Sumit — Columbia University Health Sciences
- Study coordinator: Mohan, Sumit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.