Improving heart function in patients with hypertrophic cardiomyopathy
Targeting Energetics to Improve Outcomes in Hypertrophic Cardiomyopathy
This study is looking at ways to improve how heart cells produce energy in people with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle is too thick, to help slow down or even reverse the problems it causes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11063988 on NIH RePORTER |
What this research studies
This research investigates how to enhance mitochondrial function in patients with hypertrophic cardiomyopathy (HCM), a condition characterized by thickened heart muscle that can lead to heart failure. The study aims to understand the energy demands of heart cells and how mutations affect their ability to produce energy efficiently. By targeting the underlying energetic issues, the research seeks to delay or reverse the progression of HCM and its associated complications, such as diastolic dysfunction and arrhythmias.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hypertrophic cardiomyopathy, particularly those experiencing symptoms related to heart function.
Not a fit: Patients without a diagnosis of hypertrophic cardiomyopathy or those with advanced heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and quality of life for patients with hypertrophic cardiomyopathy.
How similar studies have performed: Previous research has shown promise in targeting mitochondrial function to improve heart conditions, suggesting that this approach could be effective for hypertrophic cardiomyopathy as well.
Where this research is happening
Boston, United States
- Boston Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Luptak, Ivan — Boston Medical Center
- Study coordinator: Luptak, Ivan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.