Boosting heart cell energy in hypertrophic cardiomyopathy
Official title: Targeting Energetics to Improve Outcomes in Hypertrophic Cardiomyopathy
Funded at Boston Medical Center · NIH-11323876 · Data updated 2026-11-12
New approaches to improve mitochondrial energy in heart cells for people with hypertrophic cardiomyopathy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $770,364 |
| NIH project number | 5R01HL166606-03 |
| Project ID | NIH-11323876 on NIH RePORTER |
Who could benefit from this research
✓Could help
People diagnosed with hypertrophic cardiomyopathy, especially those with known sarcomere gene mutations or early diastolic dysfunction, are the most likely candidates.
✕Less likely to help
Patients with unrelated cardiac conditions or with very advanced, end-stage heart failure may not receive direct benefit from this research.
What this research studies
This project looks at why sarcomere gene changes make heart muscle cells use more energy and how that extra demand damages mitochondria and calcium handling. The team will study patient tissue, lab models, and targeted interventions to restore ATP production and reduce harmful byproducts like ADP and reactive oxygen. The goal is to reverse diastolic dysfunction and slow or stop progression from thickened heart muscle to heart failure. If lab and tissue results are promising, the work could move toward treatments to test in patients.
Why it matters
Potential benefit: Could delay or reverse heart muscle thickening and reduce heart failure symptoms by restoring healthier energy use in heart cells.
How similar studies have gone: Some prior studies show metabolic or mitochondrial therapies can help heart function, but using energy-targeted approaches specifically for HCM is relatively new.
Where this research is happening
-
Boston Medical Center
Boston, United States Active
Researchers
- Principal investigator: Luptak, Ivan — Boston Medical Center
- Study coordinator: Luptak, Ivan
Related research
Other NIH-funded projects on the same topics.
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SGLT inhibitors for non-obstructive hypertrophic cardiomyopathy
A testing of a diabetes drug class (SGLT2 inhibitors) to help people with non-obstructive hypertrophic cardiomyopathy feel better and reduce heart-related problems.
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Using big biobanks to understand rare gene changes in hypertrophic cardiomyopathy
A large study will look at genetic data and health information from many people to better understand how rare gene changes influence hypertrophic cardiomyopathy and its risks.
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Understanding heart disease in hypertrophic cardiomyopathy through heart tissue and blood analysis
Researchers are studying people with hypertrophic cardiomyopathy to see how genes and signaling in heart tissue and blood relate to disease progression and risk of serious heart problems.
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Myosin binding protein C variants and heart disease
A doctor-scientist at the University of Michigan is studying how certain genetic changes in a heart protein (MYBPC3) cause hypertrophic cardiomyopathy and whether fixing the protein or its interactions could help people with this condition.
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MEK inhibitor for severe infantile heart failure in Noonan and related RASopathies
A 12-month, multi-site trial tests whether the medicine trametinib can help infants with life-threatening heart failure due to Noonan syndrome and related genetic conditions.
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MEK inhibitor shows promise for serious infant heart disease in Noonan/RASopathies
A multi-site study tests whether the drug trametinib can help infants with severe heart muscle thickening caused by Noonan syndrome and related RASopathies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.