Boosting heart cell energy in hypertrophic cardiomyopathy
Targeting Energetics to Improve Outcomes in Hypertrophic Cardiomyopathy
New approaches to improve mitochondrial energy in heart cells for people with hypertrophic cardiomyopathy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11323876 on NIH RePORTER |
What this research studies
This project looks at why sarcomere gene changes make heart muscle cells use more energy and how that extra demand damages mitochondria and calcium handling. The team will study patient tissue, lab models, and targeted interventions to restore ATP production and reduce harmful byproducts like ADP and reactive oxygen. The goal is to reverse diastolic dysfunction and slow or stop progression from thickened heart muscle to heart failure. If lab and tissue results are promising, the work could move toward treatments to test in patients.
Who could benefit from this research
Good fit: People diagnosed with hypertrophic cardiomyopathy, especially those with known sarcomere gene mutations or early diastolic dysfunction, are the most likely candidates.
Not a fit: Patients with unrelated cardiac conditions or with very advanced, end-stage heart failure may not receive direct benefit from this research.
Why it matters
Potential benefit: Could delay or reverse heart muscle thickening and reduce heart failure symptoms by restoring healthier energy use in heart cells.
How similar studies have performed: Some prior studies show metabolic or mitochondrial therapies can help heart function, but using energy-targeted approaches specifically for HCM is relatively new.
Where this research is happening
Boston, United States
- Boston Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Luptak, Ivan — Boston Medical Center
- Study coordinator: Luptak, Ivan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.