Understanding the different ways hypertrophic cardiomyopathy affects patients
Hypertrophic Cardiomyopathy: Understanding the Heterogeneity of Disease Expression and Outcomes
This study is looking into why some people with hypertrophic cardiomyopathy (HCM) have more severe symptoms than others, using genetic and health information to help improve how we diagnose and manage this heart condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10903810 on NIH RePORTER |
What this research studies
This research investigates hypertrophic cardiomyopathy (HCM), a genetic heart condition that causes thickening of the heart muscle. By analyzing data from a large registry of HCM patients, the study aims to uncover the genetic and phenotypic factors that contribute to the varying severity of the disease among individuals. The research employs advanced genetic analysis and clinical assessments to identify why some patients experience severe symptoms while others have mild forms of the disease. This comprehensive approach seeks to improve diagnosis and management strategies for HCM.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with hypertrophic cardiomyopathy, particularly those with varying degrees of disease severity.
Not a fit: Patients without a diagnosis of hypertrophic cardiomyopathy or those with other unrelated cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment plans for patients with hypertrophic cardiomyopathy, improving their quality of life and health outcomes.
How similar studies have performed: Previous research has shown promising results in understanding genetic heart disorders, suggesting that this approach could yield valuable insights into hypertrophic cardiomyopathy as well.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Ho, Carolyn Y — Brigham and Women's Hospital
- Study coordinator: Ho, Carolyn Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.