Using high-intensity ultrasound to treat heart obstruction in hypertrophic cardiomyopathy
Official title: High-Intensity Ultrasound Ablation for Septal Reduction Therapy of Hypertrophic Cardiomyopathy
Funded at University of Washington · NIH-11038040 · Data updated 2026-11-12
This study is testing a new, less invasive ultrasound treatment for people with obstructive hypertrophic cardiomyopathy (HCM) to help reduce heart muscle thickness and improve heart function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 9, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $568,722 |
| NIH project number | 5R01HL160712-04 |
| Project ID | NIH-11038040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with obstructive hypertrophic cardiomyopathy who experience significant symptoms due to left ventricular outflow tract obstruction.
✕Less likely to help
Patients with non-obstructive forms of hypertrophic cardiomyopathy or those who are not experiencing severe symptoms may not benefit from this research.
What this research studies
This research focuses on developing a new treatment for obstructive hypertrophic cardiomyopathy (HCM), a condition that causes significant heart-related symptoms due to blockage in the heart's outflow tract. The approach utilizes high-intensity ultrasound to reduce the thickness of the heart muscle in a less invasive manner compared to traditional methods. By targeting specific areas of the heart while minimizing damage to surrounding tissues, this technique aims to improve patient outcomes and reduce complications. The research will optimize the ultrasound technique and prepare for initial human trials.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective treatment option for patients suffering from obstructive hypertrophic cardiomyopathy.
How similar studies have gone: Previous research has shown promise in using ultrasound techniques for cardiac treatments, suggesting potential success for this novel approach.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Nazer, Babak — University of Washington
- Study coordinator: Nazer, Babak
Related research
Other NIH-funded projects on the same topics.
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High-Intensity Ultrasound to Shrink the Septum in Hypertrophic Cardiomyopathy
A new, less invasive ultrasound-based treatment is being developed to reduce the thickened heart septum in people with obstructive hypertrophic cardiomyopathy.
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Using ultrasound to treat obstructive hypertrophic cardiomyopathy
This study is testing a new, less invasive treatment for people with obstructive hypertrophic cardiomyopathy (oHCM) that uses ultrasound to help reduce heart muscle blockage, making it a safer option than traditional surgery.
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Using ultrasound to treat obstructive hypertrophic cardiomyopathy
This study is testing a new, less invasive ultrasound treatment for people with obstructive hypertrophic cardiomyopathy (oHCM) to help reduce heart blockage safely, especially for those who can't have traditional surgery.
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SGLT inhibitors for non-obstructive hypertrophic cardiomyopathy
A testing of a diabetes drug class (SGLT2 inhibitors) to help people with non-obstructive hypertrophic cardiomyopathy feel better and reduce heart-related problems.
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Using big biobanks to understand rare gene changes in hypertrophic cardiomyopathy
A large study will look at genetic data and health information from many people to better understand how rare gene changes influence hypertrophic cardiomyopathy and its risks.
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Understanding heart disease in hypertrophic cardiomyopathy through heart tissue and blood analysis
Researchers are studying people with hypertrophic cardiomyopathy to see how genes and signaling in heart tissue and blood relate to disease progression and risk of serious heart problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.