Understanding heart muscle changes in hypertrophic cardiomyopathy to predict serious heart events
Proteomics profiling in hypertrophic cardiomyopathy and cardiac event prediction
This study is looking at hypertrophic cardiomyopathy (HCM), a heart condition that can cause serious problems, to find out how it affects people and to help doctors better predict who might be at risk for complications, so they can provide better care over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11063799 on NIH RePORTER |
What this research studies
This research investigates hypertrophic cardiomyopathy (HCM), a common genetic heart condition that can lead to serious cardiovascular events like arrhythmias and heart failure. By analyzing blood and heart tissue samples from patients in a large biorepository, the study aims to identify specific molecular changes associated with HCM and its complications. The goal is to improve the ability to predict which patients are at higher risk for adverse events, thereby guiding more effective preventive treatments. Patients will be followed closely over several years to gather comprehensive health data.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hypertrophic cardiomyopathy, particularly those who may be at risk for major adverse cardiovascular events.
Not a fit: Patients without a diagnosis of hypertrophic cardiomyopathy or those with other unrelated cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prediction of serious heart events in patients with hypertrophic cardiomyopathy, allowing for timely and targeted interventions.
How similar studies have performed: Previous research has shown promise in using proteomic profiling to understand heart diseases, suggesting that this approach could yield valuable insights for hypertrophic cardiomyopathy as well.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Shimada, Yuichi — Columbia University Health Sciences
- Study coordinator: Shimada, Yuichi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.