Clinical trial Recruiting at 1 site Observational Ages 18 and up

Assessing lymphoma treatment response using advanced DNA analysis

Official title: Early Assessment of Aggressive B-Cell Lymphoma Treatment Response and Prediction of Recurrence Using Phased Variant Analysis With Next-Generation Sequencing

Run by National Taiwan University Hospital · NCT06550427 · Data updated 2026-11-12

This study is testing if analyzing DNA from blood can help doctors see how well treatment is working for patients with aggressive B-cell lymphoma without using radiation from scans.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment200 (estimated)
SponsorNational Taiwan University Hospital
Academic / other
Locations1 site (Taipei)
StatusRecruiting
StartedAugust 9, 2024
Main results expectedJuly 31, 2027
Study endsJuly 31, 2027
Registry record updatedJune 17, 2025
Trial IDNCT06550427 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older with pathology-proven aggressive B-cell lymphoma.

Probably not a fit

Patients with non-aggressive forms of lymphoma or those under 18 years old may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on evaluating the treatment response in patients with aggressive B-cell lymphoma through the analysis of circulating tumor DNA (ctDNA) using phased variant analysis and next-generation sequencing (NGS). The study aims to provide a safer alternative to traditional imaging methods like CT and PET scans, which involve radiation exposure. By analyzing ctDNA, researchers hope to gain insights into the molecular characteristics of the tumor and the patient's clinical status, potentially leading to more accurate early assessments of treatment efficacy.

Why it matters

Potential benefit: If successful, this approach could lead to safer and more effective monitoring of lymphoma treatment responses, improving patient outcomes.

How similar studies have gone: While the use of ctDNA analysis is gaining traction, this specific approach using phased variant analysis in lymphoma treatment response assessment is relatively novel and has not been extensively tested in prior studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* • Pathology proven lymphoma

  * Age ≥ 18 years old

Exclusion Criteria:

* none

Where it's running

  • National Taiwan University Hospital
    Taipei, Taiwan
    Recruiting

Study contacts

  • Principal investigator: Tai-Chung Huang, Ph.D — National Taiwan University Hospital
  • Study coordinator: Tai-Chung Huang, Ph.D
  • Email: tch01@ntu.edu.tw
  • Phone: +886-972-651392

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.