NIH-funded research R21 grant

Finding ways to identify when non-Hodgkin lymphoma comes back using electronic health records.

Official title: Identifying Recurrent Non-Hodgkin Lymphoma in Electronic Health Data

Funded at Univ of Massachusetts Med Sch Worcester · NIH-10424952 · Data updated 2026-11-12

This study is working on new ways to use health records to better spot when non-Hodgkin lymphoma comes back, especially for those with diffuse large B-cell lymphoma or follicular lymphoma, so that patients can get better care and monitoring.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionUniv of Massachusetts Med Sch Worcester
NIH-funded
Lab location1 site (Worcester, United States)
Project startSeptember 14, 2022
Project endMarch 31, 2026
Funding year2022
Award (this year)$442,176
NIH project number1R21CA269425-01
Project IDNIH-10424952 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include individuals aged 18 and older who have been diagnosed with diffuse large B-cell lymphoma or follicular lymphoma.

Less likely to help

Patients with other types of cancer or those who have not been diagnosed with non-Hodgkin lymphoma may not benefit from this research.

What this research studies

This research aims to develop innovative algorithms that utilize electronic health records (EHRs) to accurately identify recurrences of non-Hodgkin lymphoma (NHL), specifically focusing on two common types: diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). By employing both rule-based and machine learning approaches, the study will analyze data from diverse healthcare systems to uncover patterns and risk factors associated with lymphoma recurrence. This could lead to improved monitoring and treatment strategies for patients who have been diagnosed with NHL.

Why it matters

Potential benefit: If successful, this research could enhance the ability to detect lymphoma recurrences early, leading to better patient outcomes and tailored treatment plans.

How similar studies have gone: Other research has successfully utilized electronic health records to improve cancer outcome tracking, indicating that this approach has potential for success.

Where this research is happening

  • Univ of Massachusetts Med Sch Worcester
    Worcester, United States
    Active

Researchers

  • Principal investigator: Epstein, Mara Meyer — Univ of Massachusetts Med Sch Worcester
  • Study coordinator: Epstein, Mara Meyer

Related research

Other NIH-funded projects on the same topics.

  • Novel combination therapy for non-Hodgkin lymphoma in people and dogs

    A new treatment combo using an oncolytic virus and other therapies is being tested to help people with hard-to-treat non-Hodgkin lymphoma, with studies also involving dogs to better understand responses.

    NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11473229

  • Combination therapy approach for non-Hodgkin lymphoma (NHL)

    A Mayo Clinic team is testing a new combination treatment for non-Hodgkin lymphoma to improve responses in patients and in dogs with similar disease.

    NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11402652

  • Multi-antigen T cell therapy for relapsed NHL

    A patient-derived T cell therapy called MT-601 targets six tumor-associated antigens to help treat relapsed non-Hodgkin lymphoma after other therapies may have failed.

    NIH research Marker Therapeutics, INC. · Houston, United States · NIH-11374461

  • Precision targeted radioactive antibody therapy for non-Hodgkin lymphoma

    Researchers are developing more precise radioactive antibodies to treat people with CD20-positive non-Hodgkin lymphoma.

    NIH research Washington University · Saint Louis, United States · NIH-11241103

  • AI-designed drugs targeting a common lymphoma mutation (MYD88 L265P)

    Researchers are using artificial intelligence to create and test new drugs that block a common MYD88 mutation found in many B‑cell non‑Hodgkin lymphomas to help people with these cancers.

    NIH research Baylor College of Medicine · Houston, United States · NIH-11235842

  • New combination therapy for non-Hodgkin lymphoma

    A virus-based combination treatment aims to boost the immune system to help people and companion dogs with relapsed or treatment-resistant diffuse large B-cell lymphoma.

    NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11211672

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.