Condition
B-cell Lymphoma clinical trials and research
As of November 12, 2026, Find a Trial lists 40 B-cell Lymphoma clinical trials that are recruiting, at sites in 21 countries (most in United States (19), China (18), Australia (5)). By phase: Phase 1 (12), Phase 1/2 (10), Phase 2 (9), Phase 3 (2). The most active sponsors are M.D. Anderson Cancer Center (3), Nurix Therapeutics, Inc. (2), BeOne Medicines (2). There are also 33 NIH-funded research projects on B-cell Lymphoma, with $14.1 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 40Clinical trials
- 33NIH research projects
- 21Countries
Newest B-cell Lymphoma clinical trials
All recruiting trials (40)
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In Vivo CD19/CD20 CAR T-Cell Therapy for Relapsed or Refractory B-Cell Lymphoma
This early-phase trial tests a one-time in vivo CAR T-cell therapy (SL1617) for people with relapsed or refractory B-cell lymphoma to see if it is safe and tolerable.
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Toxin exposure and immune factors in B-cell non-Hodgkin lymphoma
This study tests how toxin exposure, genetics, and immune issues relate to B-cell non-Hodgkin lymphoma in active-duty service members and other Military Health System beneficiaries.
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FXS0683 in relapsed or refractory blood cancers
This first‑in‑human study tests FXS0683 in adults with relapsed or refractory B‑cell lymphoma, AML, MDS, or ALL to see if it is safe, how the drug behaves in the body, and whether it shows any antitumor activity.
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Bendamustine vs standard lymphodepletion before CAR-T in LBCL
This trial tests whether bendamustine can replace the standard bendamustine-free lymphodepletion before CAR-T therapy in adults with large B-cell lymphoma who have had prior treatment.
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CD19-targeted CAR-T cells that make p40 for relapsed or refractory CD19-positive blood cancers
This trial will try a patient's own CD19-directed CAR-T cells engineered to produce p40 to see if they work better and last longer in adults with relapsed or refractory CD19-positive blood cancers.
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NX-5948 plus other medicines for B-cell cancers
This trial tests NX-5948 in combination with venetoclax, with or without anti-CD20 antibodies, for adults with CLL/SLL or B-cell lymphoma that has returned or worsened or is newly diagnosed but needing treatment.
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NX-5948 vs Pirtobrutinib in R/R CLL/SLL
This study tests NX-5948 against pirtobrutinib in people with relapsed or refractory CLL/SLL who have previously tried a covalent BTK inhibitor.
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BAFF‑R CAR‑T treatment for adults with CD19‑negative relapsed or refractory B‑cell lymphoma
This trial will see if BAFF‑R CAR‑T cells are safe and tolerable for adults whose B‑cell lymphoma has returned or not responded and is CD19‑negative.
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Zanubrutinib plus rituximab for secondary HLH linked to B‑cell lymphoma
This test tries zanubrutinib together with rituximab (plus short steroids and ruxolitinib, with emapalumab if needed) to treat people who have secondary HLH caused by B‑cell lymphoma.
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Anti-CD19 gene therapy for B-cell lymphoma
This trial will try an Anti-CD19 gene injection in adults with relapsed or refractory B-cell lymphoma to see if it is safe and can shrink tumors.
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New therapy dose test for people with prior B-cell cancers
This early-phase study tests different doses of LY4152199 to see if it is safe and effective for people who have already been treated for certain B-cell lymphomas.
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U01 (ssCART-19) treatment for relapsed or refractory B‑cell lymphoma
This treatment will try CD19-targeted CAR‑T cells called ssCART‑19 (with an IL‑6 silencing element) in people aged 2–75 whose B‑cell lymphoma has relapsed or not responded to prior therapy.
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BCOR and ZC3H12 knockout CD19 CAR-T therapy for relapsed/refractory B‑cell lymphoma
This will try an autologous CD19 CAR‑T treatment with two genes (BCOR and ZC3H12) turned off to see if it works better for adults whose B‑cell lymphoma has returned or not responded to prior treatments.
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Evaluating a new cell therapy for B-Cell Lymphoma
This study is testing a new cell therapy for people with hard-to-treat B-cell lymphoma to see if it is safe and effective at reducing side effects compared to traditional treatments.
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Allogeneic CD19/BCMA CAR-T for relapsed or refractory B-cell and plasma cell cancers
This study will test whether an off-the-shelf CAR-T product (RN1101) that targets CD19 and BCMA can help people with relapsed or refractory B-cell lymphomas and multiple myeloma.
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Evaluating XS-04 for patients with relapsed or refractory blood cancers
This study is testing a new tablet called XS-04 to see if it is safe and how well it works for people with certain types of blood cancers that have come back or didn’t respond to other treatments.
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Using Fourth-Generation CAR-T to treat blood cancers
This study is testing a new type of CAR-T therapy to see if it can safely help people with blood cancers like Multiple Myeloma and B-cell Lymphoma.
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Comparing sonrotoclax plus zanubrutinib to placebo plus zanubrutinib for relapsed mantle cell lymphoma
This study is testing if adding sonrotoclax to zanubrutinib can help adults with relapsed mantle cell lymphoma feel better compared to just taking zanubrutinib with a placebo.
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Investigating a new cancer treatment for relapsed or refractory B-cell malignancies
This study is testing a new cancer drug called BGB-16673 combined with other treatments to see if it can help people with tough-to-treat B-cell cancers feel better.
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Evaluating TQB3702 tablets with immunochemotherapy for B-cell lymphoma treatment
This study is testing if TQB3702 tablets can work better with immunochemotherapy to help people with relapsed or hard-to-treat B-cell lymphoma.
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Treatment for relapsed or refractory B-cell lymphoma using SynKIR-310
This study is testing a new treatment called SynKIR-310 to see if it can help adults with relapsed or refractory B-cell lymphoma feel better.
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Early palliative care for patients with multiple myeloma and aggressive lymphoma
This study is testing if early palliative care can improve the quality of life and comfort for people with multiple myeloma and aggressive lymphoma while they receive their usual cancer treatment.
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Combination treatment of pembrolizumab and ATRA for relapsed Hodgkin and Non-Hodgkin lymphoma
This study is testing if a combination of two treatments, pembrolizumab and ATRA, can help adults with relapsed Hodgkin and Non-Hodgkin lymphoma feel better and improve their health.
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Combining rituximab and zanubrutinib for treating indolent B-cell lymphomas
This study is testing if combining two medications, rituximab and zanubrutinib, can help people with untreated indolent B-cell lymphomas feel better and improve their treatment outcomes.
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Combining axicabtagene ciloleucel and glofitamab for treating relapsed large B cell lymphoma
This study is testing if combining two treatments, axicabtagene ciloleucel and glofitamab, can help people with relapsed large B cell lymphoma feel better and live longer.
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CLIC-2201 treatment for relapsed B cell cancers
This study is testing a new CAR-T cell therapy called CLIC-2201 to see if it can help people with relapsed B cell cancers feel better and improve their treatment outcomes.
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Treatment for relapsed B-cell lymphoma using CAR-T cells
This study is testing a new CAR-T cell therapy to see if it can help people with relapsed B-cell lymphoma feel better and improve their treatment outcomes.
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Study of crushed venetoclax tablets dissolved in liquid for pediatric patients
This study tests if crushing venetoclax tablets and mixing them with liquid helps children with blood cancers absorb the medication better and stay safe while taking it.
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Bispecific CAR-T cell therapy for relapsed B-cell cancers
This study is testing a new type of CAR-T cell therapy that targets two cancer markers to see if it helps people with relapsed B-cell cancers feel better and have better outcomes.
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CAR20(NAP)-T therapy for B-cell lymphoma
This study is testing a new treatment that uses modified immune cells to help people with B-cell lymphoma fight their cancer better, especially for those who haven't had success with other treatments.
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Evaluating CTX112 for B-cell malignancies
This study is testing a new type of CAR T cell therapy called CTX112 to see if it can safely help people with tough-to-treat B-cell cancers.
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Combination treatment for relapsed B-cell lymphoma
This study is testing a new combination of treatments for people with relapsed B-cell lymphoma to see if it helps them respond better and live longer.
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New CAR T-cell therapy for children and young adults with certain blood cancers
This study is testing a new CAR T-cell therapy that uses modified cells from children's and young adults' own blood to see if it can help treat certain tough-to-treat blood cancers.
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IKS03 treatment for advanced B cell non-Hodgkin lymphomas
This study is testing a new treatment called IKS03 for people with advanced B cell non-Hodgkin lymphoma to see how safe and effective it is.
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Local production of CAR T-cells for treating B-Cell cancers
This study is testing whether making CAR T-cells locally can help patients with B-Cell lymphoma and leukemia have a safe and effective treatment.
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Using engineered immune cells with chemotherapy to treat blood cancers
This study is testing if using special immune cells along with chemotherapy can help people with tough-to-treat blood cancers like B-cell lymphoma and leukemia feel better.
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Testing LP-168 for patients with B-cell lymphoma that hasn't responded to previous treatments
This study is testing a new oral medication called LP-168 to see if it can help patients with B-cell lymphoma who haven't had success with other treatments.
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First-line treatment for follicular and marginal zone lymphoma using mosunetuzumab and lenalidomide
This study is testing if a new combination of treatments can help adults with untreated follicular or marginal zone lymphoma feel better and improve their response to therapy.
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Using stem cell transplant and Polatuzumab Vedotin for treating B-cell lymphomas
This study is testing if a stem cell transplant followed by a new drug called Polatuzumab Vedotin can help people with different types of B-cell lymphomas feel better.
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Evaluating progastrin levels in cancer patients
This study is testing if measuring progastrin levels in the blood can help predict how cancer will progress and respond to treatment in patients with different types of cancer.
NIH-funded research (33)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Immunotherapy for B-cell lymphoma using NK T cells
A patient-focused immunotherapy approach using natural killer T cells engineered to target B-cell lymphoma, potentially offering off-the-shelf treatment options.
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Immune Evasion by HLA-E in Diffuse Large B-Cell Lymphoma
A researcher is studying how a molecule called HLA-E helps a type of blood cancer (DLBCL) hide from the immune system, with findings that may lead to better treatments.
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Cardioprotective treatment choices for DLBCL patients at risk of heart damage
Atrially, this study tests two heart-protecting drugs given during cancer treatment to see which best prevents heart problems in patients with diffuse large B-cell lymphoma who are at higher risk for heart damage.
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Translating Genomics to Practice to Overcome Disparities in DLBCL
A patient-focused project aims to understand why diffuse large B-cell lymphoma outcomes differ among people and how genomic information can guide better care for diverse groups.
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Spatially resolved single-cell biomarkers to guide B cell lymphoma therapy
Aims to map tiny details in the tumor and immune cells of diffuse large B-cell lymphoma to help predict outcomes and guide treatments.
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From pathogenesis to new targets for treating diffuse large B-cell lymphoma
A patient-focused look at how this research aims to uncover new genetic clues to guide targeted therapies for diffuse large B-cell lymphoma.
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Understanding how immune features predict immunotherapy response in diffuse large B-cell lymphoma
A study to find genomic and immune markers in diffuse large B-cell lymphoma that could help predict who benefits from immunotherapies.
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Lowering c-Myc to treat aggressive large B‑cell lymphoma
This work develops drugs that make the cancer protein c‑Myc break down, aiming to help people with aggressive large B‑cell lymphoma that overproduce c‑Myc.
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EBV-related lymphoma in people with immune deficiency: understanding what drives the disease
A doctor-scientist team will study a type of blood cancer linked to the Epstein-Barr virus in people with immune system problems to learn what makes it worse and how we can diagnose and treat it better.
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Computer models to improve combination treatments for diffuse large B‑cell lymphoma
This project builds computer simulations to help design better combination drug regimens for people with diffuse large B‑cell lymphoma.
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Blocking EGR1 to treat aggressive diffuse large B‑cell lymphoma
This project tests blocking a protein called EGR1 to help people with the aggressive ABC type of diffuse large B‑cell lymphoma who don't respond well to standard therapy.
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A new chemotherapy option for diffuse large B‑cell lymphoma
This project develops a new chemotherapy drug intended to kill diffuse large B‑cell lymphoma cells, including cancers that don't respond to current treatment.
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EBV-positive diffuse large B-cell lymphoma in people with weakened immune systems
Researchers will compare tumor and virus features in people with EBV-positive diffuse large B-cell lymphoma who have weakened immune systems from HIV or medical treatments to better link biology to health outcomes.
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Understanding how EBV affects lymphoma in patients with weakened immune systems
This study is looking at how the Epstein-Barr virus affects a type of cancer called diffuse large B-cell lymphoma, especially in people with weakened immune systems, like those with HIV, to help find better ways to diagnose and treat this illness.
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NKT cell therapy for B‑cell lymphoma
This project offers an off‑the‑shelf immune cell treatment using engineered natural killer T (NKT) cells for adults with B‑cell non‑Hodgkin lymphoma.
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Spatial immune cell maps for aggressive B‑cell lymphoma
Researchers are using advanced single‑cell imaging to map cancer and immune cells in aggressive B‑cell lymphomas to find markers that could help guide treatment for adults.
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New Ways to Treat Diffuse Large B Cell Lymphoma
This project explores the genetic differences in diffuse large B cell lymphoma to discover new treatment options for patients.
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Understanding how genes affect immune responses in lymphoma treatment
This study is looking at how the immune system interacts with diffuse large B cell lymphoma (DLBCL) to find out which genetic traits might help predict how well patients will respond to immunotherapy, so that treatments can be better tailored for those whose cancer has come back or hasn’t responded to other treatments.
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Understanding how specific mutations in EZH2 affect B-cell lymphoma
This study is looking at how two different changes in the EZH2 gene affect B-cell lymphoma, using special mice to see how these changes influence the growth and survival of B-cells, which could help us understand how this type of cancer develops.
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Using blood tests to tailor treatment for lymphoma patients
This study is looking at how a simple blood test can help doctors tailor treatment for people newly diagnosed with diffuse large B-cell lymphoma, so they can get the right amount of therapy to reduce side effects while still being effective.
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Targeting a protein involved in aggressive B-cell lymphoma
This study is looking at a type of aggressive lymphoma called double and triple-hit lymphomas to understand how a protein named TBL1X affects the disease, with the goal of finding better treatments to help patients live longer and healthier lives.
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Developing computer models for combination therapy in aggressive lymphomas
This study is looking at how different combinations of drugs can work together to treat Diffuse Large B-Cell Lymphoma (DLBCL) better, using computer simulations to understand how these treatments might affect different patients and their unique tumors.
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A new treatment for diffuse large B-cell lymphoma
This study is testing a new treatment for diffuse large B-cell lymphoma (DLBCL) using a special compound that has shown promise in lab tests, and it's designed for patients who haven't had success with current therapies.
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Targeting genetic changes in aggressive lymphoma for better treatment
This study is looking at how certain changes in genes on chromosome 18 can make diffuse large B-cell lymphoma (DLBCL) more aggressive, and it aims to create personalized treatments using new medicines that target these genetic markers to help improve outcomes for patients.
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Investigating EGR1 signaling pathways in aggressive lymphoma
This study is looking at a tough type of lymphoma called ABC DLBCL to figure out why some treatments don’t work and hopes to find new ways to help patients who haven’t had success with current therapies.
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Understanding how B-cell lymphoma evades the immune system
This study is looking at how certain blood cancers called B-cell lymphomas hide from the immune system and how a molecule named FCRLA helps them do that, with the goal of finding new ways to boost the immune response and improve treatments for patients.
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Investigating new treatment targets for diffuse large B cell lymphoma
This study is looking at a tough type of cancer called diffuse large B cell lymphoma (DLBCL) to find new ways to treat it by exploring the genes that might be causing the cancer to behave differently, and it’s for patients who are facing challenges with their current treatments.
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Identifying important cell markers in B cell lymphoma
This study is looking at a common type of lymphoma called Diffuse Large B-Cell Lymphoma (DLBCL) to find new ways to predict how well patients will respond to treatment by examining both cancer and non-cancer cells in the tumor, which could help create more personalized and effective therapies.
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Understanding how BCL10 mutations affect treatment resistance in a type of lymphoma
This study is looking at how certain changes in a gene called BCL10 might make it harder for people with diffuse large B cell lymphoma to respond to standard treatments, with the goal of finding better ways to help those patients.
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Identifying biomarkers for HIV-related lymphoma in Malawi and South Africa
This study is looking at how certain markers in tumors can help doctors better diagnose and treat HIV-related lymphoma in patients in Malawi and South Africa, aiming to improve care for those facing this challenge.
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Understanding how MYC gene activation affects diffuse large B-cell lymphoma
This study is looking at how a gene called MYC behaves in a type of cancer called diffuse large B-cell lymphoma (DLBCL) to find new ways to improve treatments and help doctors predict how the disease will progress for patients.
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Understanding how the surrounding tissue affects B-cell lymphoma growth and immune response
This study is looking at how certain cells and structures around lymphoma tumors help the cancer grow and avoid the immune system, with the goal of finding new ways to treat patients with diffuse large B-cell lymphoma.
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Identifying genetic markers for better treatment of B-cell lymphoma
This study is looking at how certain genes might help doctors understand how well patients with diffuse large B-cell lymphoma (DLBCL) will respond to common treatments, so they can improve care and outcomes for everyone affected by this type of cancer.
Related topics
Quick answers
How many B-cell Lymphoma clinical trials are recruiting right now?
40, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 21 countries. The most sites are in United States (19 trials), China (18 trials), Australia (5 trials), Canada (4 trials), Italy (4 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 12, Phase 1/2: 10, Phase 2: 9, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.