Clinical trial Recruiting at 1 site Observational Ages 18 and up

Exploring immune responses in Hodgkin's lymphoma patients treated with pembrolizumab

Official title: Immunological Senescence Phenotype as a Resistance Profile to Pembrolizumab in Patients With Relapsed/Refractory Hodgkin's Lymphoma

Run by IRCCS Azienda Ospedaliero-Universitaria di Bologna · NCT06733987 · Data updated 2026-11-12

This study is trying to see how the immune system of patients with relapsed Hodgkin's lymphoma responds to the treatment pembrolizumab to help improve future therapies.

More Hodgkin Lymphoma trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment40 (estimated)
SponsorIRCCS Azienda Ospedaliero-Universitaria di Bologna
Academic / other
Drugs / interventionsPembrolizumab
Locations1 site (Bologna)
StatusRecruiting
StartedAugust 1, 2024
Main results expectedFebruary 1, 2027
Study endsFebruary 1, 2027
Registry record updatedDecember 13, 2024
Trial IDNCT06733987 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older with relapsed or refractory classic Hodgkin Lymphoma who are eligible for treatment with pembrolizumab.

Probably not a fit

Patients who are not candidates for pembrolizumab treatment or those with other forms of lymphoma may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with relapsed or refractory classic Hodgkin Lymphoma who are being treated with pembrolizumab at the IRCCS AOU of Bologna. It involves collecting peripheral blood samples from participants before and during their treatment to analyze the immunological senescence phenotype. The study aims to understand how these immune characteristics may influence treatment resistance and patient outcomes. The findings could provide insights into optimizing therapy for Hodgkin's lymphoma patients.

Why it matters

Potential benefit: If successful, this study could help identify immune profiles that predict treatment responses, leading to more personalized and effective therapies for Hodgkin's lymphoma.

How similar studies have gone: While similar studies have explored immune responses in cancer treatments, this specific approach to analyzing immunological senescence in Hodgkin's lymphoma with pembrolizumab is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients of both sexes aged ≥ 18 years at enrollment
* Patients affected by cHL R/R candidate to receive a treatment with Pembrolizumab
* Signature of informed consent

Exclusion Criteria:

* none

Where it's running

  • IRCCS Azienda Ospedaliero - Universitaria di Bologna
    Bologna, Italy
    Recruiting

Study contacts

  • Principal investigator: Pier Luigi Zinzani, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
  • Study coordinator: Pier Luigi Zinzani, MD
  • Email: pierluigi.zinzani@unibo.it
  • Phone: +390512144042

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.