Exploring immune responses in Hodgkin's lymphoma patients treated with pembrolizumab
Official title: Immunological Senescence Phenotype as a Resistance Profile to Pembrolizumab in Patients With Relapsed/Refractory Hodgkin's Lymphoma
Run by IRCCS Azienda Ospedaliero-Universitaria di Bologna · NCT06733987 · Data updated 2026-11-12
This study is trying to see how the immune system of patients with relapsed Hodgkin's lymphoma responds to the treatment pembrolizumab to help improve future therapies.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna Academic / other |
| Drugs / interventions | Pembrolizumab |
| Locations | 1 site (Bologna) |
| Status | Recruiting |
| Started | August 1, 2024 |
| Main results expected | February 1, 2027 |
| Study ends | February 1, 2027 |
| Registry record updated | December 13, 2024 |
| Trial ID | NCT06733987 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with relapsed or refractory classic Hodgkin Lymphoma who are eligible for treatment with pembrolizumab.
✕Probably not a fit
Patients who are not candidates for pembrolizumab treatment or those with other forms of lymphoma may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients with relapsed or refractory classic Hodgkin Lymphoma who are being treated with pembrolizumab at the IRCCS AOU of Bologna. It involves collecting peripheral blood samples from participants before and during their treatment to analyze the immunological senescence phenotype. The study aims to understand how these immune characteristics may influence treatment resistance and patient outcomes. The findings could provide insights into optimizing therapy for Hodgkin's lymphoma patients.
Why it matters
Potential benefit: If successful, this study could help identify immune profiles that predict treatment responses, leading to more personalized and effective therapies for Hodgkin's lymphoma.
How similar studies have gone: While similar studies have explored immune responses in cancer treatments, this specific approach to analyzing immunological senescence in Hodgkin's lymphoma with pembrolizumab is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients of both sexes aged ≥ 18 years at enrollment * Patients affected by cHL R/R candidate to receive a treatment with Pembrolizumab * Signature of informed consent Exclusion Criteria: * none
Where it's running
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IRCCS Azienda Ospedaliero - Universitaria di Bologna
Bologna, Italy Recruiting
Study contacts
- Principal investigator: Pier Luigi Zinzani, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Study coordinator: Pier Luigi Zinzani, MD
- Email: pierluigi.zinzani@unibo.it
- Phone: +390512144042
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.