Improving health for lymphoma survivors through diet and exercise
Lifestyle Intervention of Food and Exercise for Lymphoma Survivors (LIFE - L)
This study tests if following a Mediterranean diet and doing home exercises can help lymphoma patients on chemotherapy finish their treatment and feel better during it.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 140 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Miami Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Miami, Florida) |
| Trial ID | NCT05839210 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of a Mediterranean diet and a home-based exercise program on lymphoma patients undergoing chemotherapy. The goal is to determine if these lifestyle interventions can enhance treatment completion rates and alleviate treatment-related side effects. Participants will be randomized into either the intervention group or a waitlist-control group, with supportive materials provided to assist in adherence to the program.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with untreated Non-Hodgkin or Hodgkin lymphoma who are scheduled for at least 6 cycles of chemotherapy.
Not a fit: Patients who are not undergoing chemotherapy or those with a performance status grade of 3 or higher may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved health outcomes and quality of life for lymphoma survivors during chemotherapy.
How similar studies have performed: Other studies have shown positive outcomes with lifestyle interventions in cancer care, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. 18 years of age or older 2. Any sex/gender 3. Able to provide consent 4. Able to read or understand English or Spanish 5. Diagnosis of untreated Non-Hodgkin or Hodgkin lymphoma, requiring at least 6 cycles of chemotherapy, being treated with one of the following therapies at discretion of PIs: 1. R-CHOP or R-CHOP-like regimen 2. BR 3. BV-AVD or ABVD or checkpoint inhibitor+AVD 6. ECOG Performance Status grade of \<2 a. PI approval needed if ECOG = 2 7. Approval from treating oncologist, confirmed via email or in writing 8. Delivery of chemotherapy treatments at one of the following institutions: 1. Sylvester Comprehensive Cancer Center (including satellite/network sites) 2. University of Miami Hospital/UHealth Tower 9. Internet access on a smart phone, tablet, or computer 10. Willing to be randomized to a Mediterranean diet/home-based physical activity intervention or waitlist-control group. Exclusion Criteria: 1. Individuals younger than 18 years of age 2. Unable to provide consent 3. Unable to read or understand English or Spanish 4. Any contraindication for diet change or exercising as determined by physician 5. Currently following a vegan or ketogenic diet, or consuming more than 5 servings of fruit and vegetables per day for the prior month 6. Engaging in \>150 minutes of moderate to vigorous physical activity on average per week for the prior month 7. History of dementia or major psychiatric disease 8. History of recent (≤1 yr) stroke, myocardial infarction or congestive heart failure
Where this trial is running
Miami, Florida
- University of Miami — Miami, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Tracy E Crane, Phd, RDN — University of Miami
- Study coordinator: Tracy E Crane, PhD, RDN
- Email: tecrane@med.miami.edu
- Phone: 305-243-8255
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.