New combination therapy for non-Hodgkin lymphoma
Translation of a novel combination therapy approach for non-Hodgkin lymphoma
['FUNDING_U01'] · MAYO CLINIC ROCHESTER · NIH-10918057
This study is looking at a new treatment approach for people with diffuse large B-cell lymphoma (DLBCL), a common type of cancer, to help improve how well therapies work, especially for those with advanced cases, by learning from both human and dog cases.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10918057 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a novel combination therapy for diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin lymphoma, which often has limited treatment options. The approach aims to understand the mechanisms behind immunotherapy resistance and improve treatment responses for patients with advanced forms of this cancer. By studying both human and canine cases of DLBCL, the research seeks to leverage similarities in tumor environments to enhance therapeutic strategies. The use of an engineered oncolytic virus is also being explored to provide a new avenue for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with diffuse large B-cell lymphoma, particularly those with relapsed or refractory cases.
Not a fit: Patients with other types of non-Hodgkin lymphoma or those who are not experiencing relapsed or refractory disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients suffering from non-Hodgkin lymphoma.
How similar studies have performed: Previous research has shown promise in using combination therapies and immunotherapy for similar cancers, indicating potential for success in this novel approach.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAIK, SHRUTHI — MAYO CLINIC ROCHESTER
- Study coordinator: NAIK, SHRUTHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers