Investigating heart and brain function in survivors of Hodgkin Lymphoma
Official title: Cardiopulmonary function and cerebral blood flow in Hodgkin Lymphoma survivors
Funded at St. Jude Children's Research Hospital · NIH-11009048 · Data updated 2026-11-12
This study is looking at how treatments for Hodgkin Lymphoma might impact heart and lung health, and how that could affect brain function in survivors, so if you're a survivor, we’d love for you to join us to help understand these connections better!
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | January 8, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $212,713 |
| NIH project number | 5R21CA280230-02 |
| Project ID | NIH-11009048 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adult survivors of Hodgkin Lymphoma who have undergone treatment with bleomycin and/or radiation.
✕Less likely to help
Patients who have not been treated for Hodgkin Lymphoma or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research focuses on understanding how treatments for Hodgkin Lymphoma can lead to complications in heart and lung function, which may affect brain health in survivors. The study will compare the cerebral blood flow and oxygen levels during exercise between Hodgkin Lymphoma survivors and healthy controls. Participants will undergo various tests, including pulmonary function tests and neurocognitive assessments, to explore the relationship between cardiopulmonary health and cognitive outcomes. The goal is to uncover the mechanisms linking cancer treatment to long-term health issues.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for Hodgkin Lymphoma survivors, enhancing their quality of life.
How similar studies have gone: Previous research has indicated that similar approaches to studying the long-term effects of cancer treatments on heart and brain function have shown promising results.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Phillips, Nicholas S — St. Jude Children's Research Hospital
- Study coordinator: Phillips, Nicholas S
Related research
Other NIH-funded projects on the same topics.
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Understanding why Black and Hispanic Hodgkin lymphoma patients have worse survival
A patient-centered study to uncover social and care factors that contribute to lower survival among Black and Hispanic people with Hodgkin lymphoma across all ages.
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Novel combination therapy for non-Hodgkin lymphoma in people and dogs
A new treatment combo using an oncolytic virus and other therapies is being tested to help people with hard-to-treat non-Hodgkin lymphoma, with studies also involving dogs to better understand responses.
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Trajectories of Neurotoxicity in young Hodgkin lymphoma patients
Aging Hodgkin lymphoma patients who are adolescents or young adults may face long-lasting brain and nerve-related side effects from their cancer treatment, and this study aims to map how those problems develop over time.
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Combination therapy approach for non-Hodgkin lymphoma (NHL)
A Mayo Clinic team is testing a new combination treatment for non-Hodgkin lymphoma to improve responses in patients and in dogs with similar disease.
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Multi-antigen T cell therapy for relapsed NHL
A patient-derived T cell therapy called MT-601 targets six tumor-associated antigens to help treat relapsed non-Hodgkin lymphoma after other therapies may have failed.
-
Personalized de‑intensification of therapy for NLP Hodgkin lymphoma
A clinician-scientist at Stanford is developing a patient-centered program to tailor and reduce therapy for nodular lymphocyte-predominant Hodgkin lymphoma using tumor and blood samples.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.