Investigating Hodgkin lymphoma in people living with HIV in South Africa
Hodgkin Lymphoma in PLWH in South Africa: TB, EBV, and Tumor Molecular Markers
This study is looking at how Hodgkin lymphoma affects people living with HIV in South Africa, comparing their experiences with those who don’t have HIV, to better understand how factors like organ health and other infections might influence treatment and outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10825552 on NIH RePORTER |
What this research studies
This research focuses on understanding the outcomes of Hodgkin lymphoma (HL) in individuals living with HIV in South Africa, where their prognosis is often worse compared to those without HIV. The study will observe both HIV-positive and HIV-negative patients to assess various factors such as performance status, organ function, clinical stage, and the presence of Epstein-Barr virus (EBV) in tumors. Additionally, it will explore the impact of tuberculosis (TB) co-infection on treatment responses and mortality rates. By utilizing minimally invasive autopsy techniques, the research aims to gather comprehensive data on causes of death and treatment efficacy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Hodgkin lymphoma who are also living with HIV in South Africa.
Not a fit: Patients who do not have Hodgkin lymphoma or are not living with HIV may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and outcomes for Hodgkin lymphoma patients living with HIV.
How similar studies have performed: Previous research has shown that understanding the interplay between HIV and cancer can lead to better treatment outcomes, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Ambinder, Richard Frederick — Johns Hopkins University
- Study coordinator: Ambinder, Richard Frederick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.