Change in how kids and young adults with Hodgkin or non-Hodgkin lymphoma process medicines

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial gives two oral probe drugs (omeprazole and dextromethorphan) at scheduled times that align with routine hospital visits for lymphoma treatment, then takes blood samples to measure how the probes are metabolized by CYP3A4, CYP2C19, and CYP2D6 pathways. It is a Phase 1 interventional feasibility and acceptability study in patients aged 6–25 with a new diagnosis of Hodgkin or non-Hodgkin lymphoma. The protocol excludes patients with prior cancer therapy, severe organ dysfunction, allergy to the probes, or those requiring urgent treatment that precludes consent. Results will inform whether larger phenoconversion studies in pediatric oncology are practical and acceptable and help design future precision-medicine dosing trials.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 6-25 years of age.
* New diagnosis of Hodgkin Lymphoma or Non-Hodgkin Lymphoma.
* Able to swallow and absorb oral or nasogastric tube (NGT) administration of probe drugs.
* Able to provide written informed consent.

Exclusion Criteria:

* Failure to comply with inclusion criteria.
* Has a known previous allergy to any of the probe medications (i.e., omeprazole or dextromethorphan).
* Common Terminology Criteria for Adverse Events (CTCAE) Grade IV end organ dysfunction (i.e., hepatic, renal, gastrointestinal).
* Had previous oncological treatment (not first cancer diagnosis).
* Is a clinically unstable patient requiring intensive care admission in high-risk circumstances will not be considered eligible for consent.
* Any patient requiring urgent initiation of anti-cancer treatment outside hours where a member of the study staff is unable to approach the parent/guardian or participant for consent prior to commencing anti-cancer therapy will be ineligible for consent.
* Unable to provide written informed consent.

Where it's running

• Peter MacCallum Cancer Centre
  Melbourne, Victoria, Australia Recruiting

Study contacts

• Principal investigator: Rachel Conyers, MBBS (Hons) — Murdoch Childrens Research Institute
• Study coordinator: Rachel Conyers, MBBS (Hons)
• Email: rachel.conyers@mcri.edu.au
• Phone: +61393455522

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.