Combining international Hodgkin lymphoma data to understand long-term treatment effects
Official title: Modeling Multi-Source Data in Hodgkin Lymphoma
Funded at Tufts Medical Center · NIH-11285423 · Data updated 2026-11-12
This project brings together trial and registry data to learn how treatments affect long-term health in adults with Hodgkin lymphoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $660,541 |
| NIH project number | 5R01CA262265-05 |
| Project ID | NIH-11285423 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older with a history of Hodgkin lymphoma, particularly those treated in modern clinical trials or included in long-term registries, are the main focus.
✕Less likely to help
Children under 21, people with other types of lymphoma, or patients without long-term follow-up data are unlikely to receive direct benefit from this project.
What this research studies
I would be part of a project that pools individual patient records from more than 12,000 people with Hodgkin lymphoma drawn from 12 clinical trials and 4 large registries. The team harmonizes those records into a common format and links them to other sources like cancer registries and health care claims to track late complications such as second cancers and cardiovascular disease. Data scientists and clinicians then use statistical and modeling tools to map who is most at risk and when problems tend to appear. The work is done across international datasets and coordinated from Tufts Medical Center.
Why it matters
Potential benefit: If successful, the work could help doctors predict and prevent late treatment complications and improve long-term health and quality of life for Hodgkin lymphoma survivors.
How similar studies have gone: Previous pooled analyses and registries have given useful survivorship insights, but this large-scale harmonization and linkage of trials, registries, and administrative data is relatively novel.
Where this research is happening
-
Tufts Medical Center
Boston, United States Active
Researchers
- Principal investigator: Parsons, Susan Kenyon — Tufts Medical Center
- Study coordinator: Parsons, Susan Kenyon
Related research
Other NIH-funded projects on the same topics.
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Understanding why Black and Hispanic Hodgkin lymphoma patients have worse survival
A patient-centered study to uncover social and care factors that contribute to lower survival among Black and Hispanic people with Hodgkin lymphoma across all ages.
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Novel combination therapy for non-Hodgkin lymphoma in people and dogs
A new treatment combo using an oncolytic virus and other therapies is being tested to help people with hard-to-treat non-Hodgkin lymphoma, with studies also involving dogs to better understand responses.
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Trajectories of Neurotoxicity in young Hodgkin lymphoma patients
Aging Hodgkin lymphoma patients who are adolescents or young adults may face long-lasting brain and nerve-related side effects from their cancer treatment, and this study aims to map how those problems develop over time.
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Combination therapy approach for non-Hodgkin lymphoma (NHL)
A Mayo Clinic team is testing a new combination treatment for non-Hodgkin lymphoma to improve responses in patients and in dogs with similar disease.
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Multi-antigen T cell therapy for relapsed NHL
A patient-derived T cell therapy called MT-601 targets six tumor-associated antigens to help treat relapsed non-Hodgkin lymphoma after other therapies may have failed.
-
Personalized de‑intensification of therapy for NLP Hodgkin lymphoma
A clinician-scientist at Stanford is developing a patient-centered program to tailor and reduce therapy for nodular lymphocyte-predominant Hodgkin lymphoma using tumor and blood samples.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.