Combining international Hodgkin lymphoma data to understand long-term treatment effects
Modeling Multi-Source Data in Hodgkin Lymphoma
This project brings together trial and registry data to learn how treatments affect long-term health in adults with Hodgkin lymphoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11285423 on NIH RePORTER |
What this research studies
I would be part of a project that pools individual patient records from more than 12,000 people with Hodgkin lymphoma drawn from 12 clinical trials and 4 large registries. The team harmonizes those records into a common format and links them to other sources like cancer registries and health care claims to track late complications such as second cancers and cardiovascular disease. Data scientists and clinicians then use statistical and modeling tools to map who is most at risk and when problems tend to appear. The work is done across international datasets and coordinated from Tufts Medical Center.
Who could benefit from this research
Good fit: Adults aged 21 and older with a history of Hodgkin lymphoma, particularly those treated in modern clinical trials or included in long-term registries, are the main focus.
Not a fit: Children under 21, people with other types of lymphoma, or patients without long-term follow-up data are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, the work could help doctors predict and prevent late treatment complications and improve long-term health and quality of life for Hodgkin lymphoma survivors.
How similar studies have performed: Previous pooled analyses and registries have given useful survivorship insights, but this large-scale harmonization and linkage of trials, registries, and administrative data is relatively novel.
Where this research is happening
Boston, United States
- Tufts Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Parsons, Susan Kenyon — Tufts Medical Center
- Study coordinator: Parsons, Susan Kenyon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.