Understanding how genetics and lifestyle affect endometrial cancer recurrence

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to define specific mutational signatures in endometrial cancer patients using whole-exome sequencing. It will analyze the relationship between these mutational profiles and the molecular classification of endometrial cancer, particularly focusing on patients with non-specific profiles or p53 mutations. Additionally, the study will investigate how lifestyle risk factors such as obesity, hypertension, and diabetes mellitus correlate with these genetic profiles. The ultimate goal is to develop a methodology for detecting mutations in circulating tumor DNA to monitor recurrence in high-risk patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical diagnosis of endometrial cancer.
* Treated with uterine removal with adequate staging.

Exclusion Criteria:

* There are no exclusion criteria in this study.

Where it's running

• Faculty Hospital Královské Vinohrady
  Prague, Czechia Recruiting

Study contacts

• Principal investigator: Michael Halaška, prof. MUDr. — Medical director
• Study coordinator: Michael Halaška, prof. MUDr.
• Email: michael.halaska@fnkv.cz
• Phone: +420 296472368

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.