Understanding how genetics and lifestyle affect endometrial cancer recurrence
Molecular Classification in Relation to Prevention of Endometrial Cancer Recurrence and Lifestyle Factors
Faculty Hospital Kralovske Vinohrady · NCT06680791
This study is trying to see how genetics and lifestyle factors like obesity and diabetes affect the chances of endometrial cancer coming back in patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 280 (estimated) |
| Sex | Female |
| Sponsor | Faculty Hospital Kralovske Vinohrady (other gov) |
| Locations | 1 site (Prague) |
| Trial ID | NCT06680791 on ClinicalTrials.gov |
What this trial studies
This observational study aims to define specific mutational signatures in endometrial cancer patients using whole-exome sequencing. It will analyze the relationship between these mutational profiles and the molecular classification of endometrial cancer, particularly focusing on patients with non-specific profiles or p53 mutations. Additionally, the study will investigate how lifestyle risk factors such as obesity, hypertension, and diabetes mellitus correlate with these genetic profiles. The ultimate goal is to develop a methodology for detecting mutations in circulating tumor DNA to monitor recurrence in high-risk patients.
Who should consider this trial
Good fit: Ideal candidates for this study are women clinically diagnosed with endometrial cancer who have undergone uterine removal with adequate staging.
Not a fit: Patients who do not have a clinical diagnosis of endometrial cancer will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved personalized treatment strategies and monitoring for patients with endometrial cancer.
How similar studies have performed: Other studies have shown promise in using genetic profiling to inform treatment decisions in cancer, suggesting this approach may be beneficial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of endometrial cancer. * Treated with uterine removal with adequate staging. Exclusion Criteria: * There are no exclusion criteria in this study.
Where this trial is running
Prague
- Faculty Hospital Královské Vinohrady — Prague, Czechia (RECRUITING)
Study contacts
- Principal investigator: Michael Halaška, prof. MUDr. — Medical director
- Study coordinator: Michael Halaška, prof. MUDr.
- Email: michael.halaska@fnkv.cz
- Phone: +420 296472368
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Endometrial Cancer, Genetic Predisposition, Risk Behavior, Endometrial cancer, BMI, Hypertension, Diabetes mellitus, Genetic predispositions