Clinical trial Recruiting at 1 site Observational Ages 18 to 90

Genetic testing for kidney disease risk in African Americans

Official title: APOL1 Genetic Testing in African Americans: Exploring Attitudes About Genetic Risk to Improve Comprehensive Kidney Risk Assessment for Patients and Families

Run by St. Louis University · NCT05656261 · Data updated 2026-11-12

This study is trying to see if knowing about certain genetic risks for kidney disease helps African Americans with high blood pressure take better care of their health.

Quick facts

Study typeObservational
Ages18 Years to 90 Years
SexAll
Enrollment600 (estimated)
SponsorSt. Louis University
Academic / other
Locations1 site (St Louis, Missouri)
StatusRecruiting
StartedJanuary 24, 2019
Main results expectedJune 30, 2026
Study endsJune 30, 2027
Registry record updatedMarch 20, 2025
Trial IDNCT05656261 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are Black or African American adults aged 18-90 who are seen in nephrology or hypertension clinics.

Probably not a fit

Patients who are cognitively impaired, terminally ill, or currently undergoing renal replacement therapy will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the prevalence of APOL1 renal risk variants among African American patients with hypertension at Saint Louis University. It aims to understand how knowledge of one's APOL1 genotype influences patient engagement in managing hypertension and other renal risk factors. Participants will complete self-administered surveys to express their attitudes towards genetic testing and its implications for kidney health. The study seeks to bridge the gap between genetic predisposition and clinical outcomes in chronic kidney disease.

Why it matters

Potential benefit: If successful, this study could lead to improved management strategies for kidney disease in African Americans by personalizing care based on genetic risk.

How similar studies have gone: Other studies have shown promise in using genetic testing to inform treatment strategies in chronic kidney disease, making this approach both relevant and potentially impactful.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Ages 18-90
* Self-Identified as Black/African American. Race will be self-identified. Patients of African ancestry who identify as multi-racial are also eligible to participate.

Exclusion Criteria:

* Cognitively impaired/unable to provide consent
* Terminally ill
* Renal replacement therapy (RRT), e.g., (but not limited to) hemodialysis, peritoneal dialysis

Where it's running

  • SSM Health Saint Louis University Hospital
    St Louis, Missouri, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.