Genetic testing for kidney disease risk in African Americans
Official title: APOL1 Genetic Testing in African Americans: Exploring Attitudes About Genetic Risk to Improve Comprehensive Kidney Risk Assessment for Patients and Families
Run by St. Louis University · NCT05656261 · Data updated 2026-11-12
This study is trying to see if knowing about certain genetic risks for kidney disease helps African Americans with high blood pressure take better care of their health.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 600 (estimated) |
| Sponsor | St. Louis University Academic / other |
| Locations | 1 site (St Louis, Missouri) |
| Status | Recruiting |
| Started | January 24, 2019 |
| Main results expected | June 30, 2026 |
| Study ends | June 30, 2027 |
| Registry record updated | March 20, 2025 |
| Trial ID | NCT05656261 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are Black or African American adults aged 18-90 who are seen in nephrology or hypertension clinics.
✕Probably not a fit
Patients who are cognitively impaired, terminally ill, or currently undergoing renal replacement therapy will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the prevalence of APOL1 renal risk variants among African American patients with hypertension at Saint Louis University. It aims to understand how knowledge of one's APOL1 genotype influences patient engagement in managing hypertension and other renal risk factors. Participants will complete self-administered surveys to express their attitudes towards genetic testing and its implications for kidney health. The study seeks to bridge the gap between genetic predisposition and clinical outcomes in chronic kidney disease.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for kidney disease in African Americans by personalizing care based on genetic risk.
How similar studies have gone: Other studies have shown promise in using genetic testing to inform treatment strategies in chronic kidney disease, making this approach both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ages 18-90 * Self-Identified as Black/African American. Race will be self-identified. Patients of African ancestry who identify as multi-racial are also eligible to participate. Exclusion Criteria: * Cognitively impaired/unable to provide consent * Terminally ill * Renal replacement therapy (RRT), e.g., (but not limited to) hemodialysis, peritoneal dialysis
Where it's running
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SSM Health Saint Louis University Hospital
St Louis, Missouri, United States Recruiting
Study contacts
- Study coordinator: Krista Lentine, PhD, MD
- Email: krista.lentine@health.slu.edu
- Phone: 314-257-3760
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.