How genetics and medication affect cognitive impairment in people with HIV
Official title: Genetic Predisposition and Pharmacogenomics of HIV-Associated Cognitive Impairment
Funded at Icahn School of Medicine at Mount Sinai · NIH-10712363 · Data updated 2026-11-12
This study is looking at how your genes might affect how well HIV treatment works for preventing memory and thinking problems, and it's for people living with HIV who want to understand more about their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 10, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $400,773 |
| NIH project number | 3R01HG010649-05S1 |
| Project ID | NIH-10712363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are experiencing cognitive impairment or are at risk for developing such impairments.
✕Less likely to help
Patients who are not living with HIV or who do not have cognitive impairment may not benefit from this research.
What this research studies
This research investigates the relationship between genetic factors and the effectiveness of antiretroviral therapy (ART) in managing cognitive impairment associated with HIV. It utilizes a large cohort of people living with HIV to analyze how genetic predispositions influence the risk of developing neurocognitive deficits, including dementia. By understanding these interactions, the research aims to improve treatment strategies and reduce the incidence of cognitive decline in this population.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment plans that enhance cognitive health for individuals living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors influencing treatment responses in chronic diseases, suggesting potential for success in this area as well.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Peter, Inga — Icahn School of Medicine at Mount Sinai
- Study coordinator: Peter, Inga
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.