Understanding Genetic Risks for Heart Attacks in People with Heart Disease
Genetic Predisposition to Myocardial Infarction in Patients with Coronary Artery Disease
This project aims to discover the genetic factors that make some people with heart disease more likely to have a heart attack.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11248176 on NIH RePORTER |
What this research studies
Many people have coronary artery disease (CAD), but only some experience a heart attack (myocardial infarction, MI). This suggests there are specific genetic reasons why some individuals are more prone to heart attacks. Researchers are looking for unique genes that are strongly linked to heart attacks, separate from the genes that cause CAD itself. They will compare the genetic information of people with CAD who have had a heart attack to those with CAD who have not, building on previous large-scale genetic collaborations. This work seeks to pinpoint these distinct genetic markers.
Who could benefit from this research
Good fit: Ideal candidates would be individuals with coronary artery disease, especially those who have or have not experienced a heart attack, who are willing to contribute genetic data.
Not a fit: Patients without coronary artery disease or those not interested in genetic research may not directly benefit from this specific project.
Why it matters
Potential benefit: If successful, this work could lead to better ways to identify individuals at high risk for heart attacks, allowing for more targeted prevention and treatment strategies.
How similar studies have performed: Previous large-scale genetic collaborations have identified several genetic locations associated with heart attacks, providing a foundation for this work.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Allayee, Hooman — University of California Los Angeles
- Study coordinator: Allayee, Hooman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.