Understanding how trihexyphenidyl works in children with dystonic cerebral palsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of trihexyphenidyl in children aged 5-17 with dystonic cerebral palsy. It aims to evaluate how the medication is metabolized in the body and whether genetic factors influence its effectiveness. The study will last for 16 weeks and will help inform the design of future clinical trials based on the findings regarding pharmacokinetics and genetic variations. It is a single-arm, nonrandomized pilot study focused on understanding the drug's biotransformation and response in pediatric patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ages 5-17 years of age
* Diagnosis of cerebral palsy and dystonia causing interference
* Parent/legal guardian of a child with a diagnosis of cerebral palsy and dystonia
* Parent/legal guardian is willing and able to provide informed permission/assent for the study

Exclusion Criteria:

* Previously or currently taking trihexyphenidyl
* Patients turning 18 years of age within the study period (16 weeks from Study Day 1)
* A language barrier for the patient that precludes communication and/or the ability to complete study-related requirements

Where it's running

• Children's Mercy Hospital Kansas City
  Kansas City, Missouri, United States Recruiting

Study contacts

• Principal investigator: Rose Gelineau-Morel, MD — Children's Mercy Kansas City
• Study coordinator: Rose Gelineau-Morel, MD
• Email: rngelineaumorel@cmh.edu
• Phone: 816-302-3331

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.