Investigating genetic factors linked to chronic lymphocytic leukemia (CLL)
Genetic Predisposition to Chronic Lymphocytic Leukemia (CLL)
This study is looking at how certain rare genetic changes, especially in the ATM gene, might make some people more likely to develop chronic lymphocytic leukemia (CLL), and it's inviting patients with known ATM gene changes to help us learn more about how these genetics relate to CLL and family cancer history.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11059143 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic predisposition to chronic lymphocytic leukemia (CLL), the most common leukemia in adults. It aims to identify rare genetic variants, particularly in the ATM gene, that may increase the risk of developing CLL. By enrolling patients with known germline ATM variants into a registry, the study will explore how these genetic factors relate to CLL clinical features and family cancer history. This approach combines genetic analysis with clinical data to provide insights into the hereditary nature of CLL.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of CLL or those who have been evaluated for germline ATM variants.
Not a fit: Patients without a family history of CLL or those who do not carry germline ATM variants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and targeted prevention strategies for individuals at high risk of CLL.
How similar studies have performed: Previous research has successfully identified genetic variants associated with other cancers, suggesting potential for success in this novel approach to CLL.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Brown, Jennifer R — Dana-Farber Cancer Inst
- Study coordinator: Brown, Jennifer R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.