Understanding and treating pulmonary hypertension in patients with severe kidney disease
Official title: Novel Mechanisms and Therapeutic Targets for Pulmonary Hypertension in End-Stage Renal Disease (K23)
Funded at Duke University · NIH-10885975 · Data updated 2026-11-12
This study is looking into why some people with severe kidney disease develop high blood pressure in their lungs and is testing new treatments to help improve their health and well-being.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $185,345 |
| NIH project number | 5K23HL155734-04 |
| Project ID | NIH-10885975 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with end-stage renal disease who are experiencing or at risk for pulmonary hypertension.
✕Less likely to help
Patients with pulmonary hypertension not related to kidney disease or those with early-stage kidney disease may not benefit from this research.
What this research studies
This research investigates the causes and potential treatments for pulmonary hypertension (PH) in patients with end-stage renal disease (ESRD). It aims to identify new biological mechanisms that contribute to PH, which affects a significant portion of ESRD patients and increases their risk of death. The study will involve rigorous clinical trials to test new therapies that target these mechanisms, moving beyond traditional treatments that focus solely on fluid management. By understanding the underlying factors that lead to PH, the research seeks to improve patient outcomes and develop more effective treatment options.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of pulmonary hypertension and improve survival rates for patients with end-stage renal disease.
How similar studies have gone: Other research has shown promise in exploring novel mechanisms of pulmonary hypertension, but this specific approach targeting ESRD is relatively novel.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Edmonston, Daniel — Duke University
- Study coordinator: Edmonston, Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.