How nutrition and inflammation affect insulin resistance in patients with severe kidney disease
Official title: Nutrition, Inflammation and Insulin Resistance in End-Stage Renal Disease
Funded at Veterans Health Administration · NIH-10908988 · Data updated 2026-11-12
This study is looking at how what you eat, inflammation, and insulin levels affect your health if you're on dialysis for kidney disease, with the goal of finding ways to help improve your nutrition and overall well-being.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | October 1, 2019 |
| Project end | September 30, 2025 |
| Funding year | 2024 |
| NIH project number | 5I01CX001755-05 |
| Project ID | NIH-10908988 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with end-stage renal disease who are currently receiving hemodialysis treatment.
✕Less likely to help
Patients who are not on hemodialysis or those with early-stage kidney disease may not benefit from this research.
What this research studies
This research investigates the relationship between nutrition, inflammation, and insulin resistance in patients undergoing hemodialysis for end-stage renal disease. It focuses on understanding how these factors contribute to protein energy wasting, a condition that affects many patients on dialysis. The study aims to explore the metabolic abnormalities that arise in these patients and how they can be addressed to improve health outcomes. By examining the effects of insulin and inflammation on muscle protein balance, the research seeks to identify potential therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved nutritional strategies and therapies that enhance the health and quality of life for patients on dialysis.
How similar studies have gone: Previous research has shown that addressing insulin resistance and inflammation can lead to improved outcomes in similar patient populations, indicating a promising avenue for this study.
Where this research is happening
-
Veterans Health Administration
Nashville, United States Active
Researchers
- Principal investigator: Ikizler, Talat Alp — Veterans Health Administration
- Study coordinator: Ikizler, Talat Alp
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.