Using integrin activation to improve the success of dialysis access in kidney disease patients
Official title: Integrin Activation to Prevent Early Arteriovenous Fistula Failure in End-stage Renal Disease Patients
Funded at University of Miami School of Medicine · NIH-11019793 · Data updated 2026-11-12
This study is looking at a new way to help improve the success of arteriovenous fistulas for people on hemodialysis, by using a special treatment that may reduce inflammation and prevent problems that can cause these important connections to fail.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $469,978 |
| NIH project number | 5R01DK136297-02 |
| Project ID | NIH-11019793 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with end-stage renal disease who require hemodialysis and are undergoing the creation of an arteriovenous fistula.
✕Less likely to help
Patients who do not require hemodialysis or those with existing complications that preclude the creation of a fistula may not benefit from this research.
What this research studies
This research focuses on improving the success rate of arteriovenous (A-V) fistulas, which are crucial for patients undergoing hemodialysis. Approximately 40% of newly created fistulas fail due to narrowing, leading to complications and the need for additional procedures. The study explores a novel approach using a specific agonist to activate the Mac-1 integrin, which may help control inflammation and prevent the narrowing of these fistulas. By targeting the inflammatory response, the research aims to enhance the maturation and functionality of A-V fistulas, ultimately benefiting patients reliant on dialysis.
Why it matters
Potential benefit: If successful, this research could significantly improve the effectiveness of dialysis access for patients with end-stage renal disease, reducing complications and healthcare costs.
How similar studies have gone: Previous research has shown promise in using integrin activation to manage inflammation in vascular access, indicating potential for success in this novel approach.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Vazquez Padron, Roberto Irenardo — University of Miami School of Medicine
- Study coordinator: Vazquez Padron, Roberto Irenardo
Related research
Other NIH-funded projects on the same topics.
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Activating a cell protein to prevent early dialysis fistula failure
This research tests a drug-like activator of the Mac-1 protein to reduce inflammation and help new dialysis fistulas work better for people with end-stage kidney disease.
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Cardiovascular changes after AV fistula creation and how autophagy affects it
A VA-led project looks at how blood vessel remodeling after AV fistula surgery may be helped by understanding and targeting autophagy.
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How life circumstances affect brain aging in people with end-stage kidney disease
This project looks at how neighborhood, income, education, and personal resilience relate to earlier memory and thinking problems in adults with end-stage kidney disease.
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Nanoparticle delivery to prevent AV fistula narrowing
A new nanoparticle-based approach aims to prevent AV fistula narrowing in people with kidney failure who rely on dialysis.
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Molecular control of arterial-to-vein remodeling in fistula maturation
This study explores how vein cells change to help arteriovenous fistulas mature, with the aim of improving outcomes for people needing hemodialysis.
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How the protein calprotectin affects healing of dialysis fistulas
Looking at whether a protein called calprotectin causes narrowing that keeps new dialysis fistulas from becoming usable for people with kidney failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.