Using integrin activation to improve the success of dialysis access in kidney disease patients
Integrin Activation to Prevent Early Arteriovenous Fistula Failure in End-stage Renal Disease Patients
['FUNDING_R01'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-11019793
This study is looking at a new way to help improve the success of arteriovenous fistulas for people on hemodialysis, by using a special treatment that may reduce inflammation and prevent problems that can cause these important connections to fail.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-11019793 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the success rate of arteriovenous (A-V) fistulas, which are crucial for patients undergoing hemodialysis. Approximately 40% of newly created fistulas fail due to narrowing, leading to complications and the need for additional procedures. The study explores a novel approach using a specific agonist to activate the Mac-1 integrin, which may help control inflammation and prevent the narrowing of these fistulas. By targeting the inflammatory response, the research aims to enhance the maturation and functionality of A-V fistulas, ultimately benefiting patients reliant on dialysis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with end-stage renal disease who require hemodialysis and are undergoing the creation of an arteriovenous fistula.
Not a fit: Patients who do not require hemodialysis or those with existing complications that preclude the creation of a fistula may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the effectiveness of dialysis access for patients with end-stage renal disease, reducing complications and healthcare costs.
How similar studies have performed: Previous research has shown promise in using integrin activation to manage inflammation in vascular access, indicating potential for success in this novel approach.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAZQUEZ PADRON, ROBERTO IRENARDO — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: VAZQUEZ PADRON, ROBERTO IRENARDO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.