How life circumstances affect memory and thinking in people with end-stage kidney disease
Official title: Social Determinants of Health, Resilience, and Premature Cognitive Aging in End-stage Renal Disease
Funded at New York University School of Medicine · NIH-11326343 · Data updated 2026-11-12
Researchers will look at how social and economic factors relate to memory and thinking problems across adults with end-stage kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 15, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $789,118 |
| NIH project number | 5R01AG077888-05 |
| Project ID | NIH-11326343 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (age 18 and older) with end-stage renal disease, especially those receiving dialysis and included in the national ESRD registry or Medicare, are the focus of this work.
✕Less likely to help
People without end-stage kidney disease, children, or those seeking an immediate treatment option for dementia are unlikely to receive direct benefit from this research.
What this research studies
You would be represented through national dialysis registry and Medicare health records that link neighborhood and socioeconomic measures to memory tests and dementia diagnoses among adults with end-stage kidney disease. The team uses 14 indicators across economic stability, education, housing, and other social domains together with patients' medical data to identify signs of premature brain aging. They will compare patterns by age and race to understand why many dialysis patients, especially Black patients, develop memory problems earlier. The work analyzes existing records and registries rather than testing new medications, aiming to point to social or care targets that could protect thinking and memory.
Why it matters
Potential benefit: If successful, this work could reveal social and health-care targets to reduce early memory loss and better support cognitive health in people on dialysis.
How similar studies have gone: Previous studies have shown high rates of cognitive problems in dialysis patients, but linking multiple social determinants to premature cognitive aging in this group is a newer approach.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Mcadams Demarco, Mara a. — New York University School of Medicine
- Study coordinator: Mcadams Demarco, Mara a.
Related research
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How life circumstances affect brain aging in people with end-stage kidney disease
This project looks at how neighborhood, income, education, and personal resilience relate to earlier memory and thinking problems in adults with end-stage kidney disease.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.