Condition

Chronic Heart Failure clinical trials and research

• 30Clinical trials
• 19NIH research projects
• 1New in 30 days
• 16Countries

Newest Chronic Heart Failure clinical trials

All recruiting trials (30)

• Voice-based detection of heart failure deterioration using Noah Labs Vox

  This study tests whether a voice-analysis app can flag worsening heart failure in adults by comparing its alerts to standard weight-based monitoring.

  Recruiting Noah Labs · Boston, Massachusetts · NCT07870395

• Mobile-based telemedicine to improve quality of life for chronic heart failure patients

  We’re testing whether a mobile phone–based program that sends reminders, education, and follow-up can improve quality of life for adults with chronic heart failure in Ethiopia.

  Recruiting Select College · Addis Ababa · NCT07650474

• Restoring gut bacteria in adults with chronic heart failure

  This trial tests whether replacing gut bacteria with healthy donor bacteria (intestinal microbiota transplantation) can reduce inflammation and improve function in adults with chronic heart failure.

  Recruiting Phase 1 Columbia University · New York, New York · NCT07490054

• Biventricular or left bundle branch pacing to improve heart pumping after TAVI

  This research will try whether implanting a cardiac resynchronization device (biventricular or left bundle branch pacing) shortly after TAVI helps people who develop a persistent left bundle branch block and have mildly reduced heart function (EF 35%–55%).

  Recruiting Semmelweis University Heart and Vascular Center · Budapest · NCT07434193

• Vericiguat for right‑ventricular function and heart remodeling in HFrEF

  This study will test whether adding vericiguat to usual heart‑failure treatment helps adults with stable HFrEF improve right‑ventricular function and heart remodeling over 12 months.

  Recruiting at 4 sites Phase 4 University Medical Centre Ljubljana · Izola and 3 other locations · NCT07405944

• Safety of finerenone in adults with chronic heart failure (LVEF ≥ 40%) in South Korea

  This project will see if finerenone is safe for adults in South Korea who have chronic heart failure with a left ventricular ejection fraction of 40% or higher while they take it as usual care.

  Recruiting Bayer · Multiple Locations · NCT07379840

• Low- versus high-volume high-intensity interval training for people with chronic heart failure

  This trial will try two different amounts of high-intensity interval exercise to see which better improves fitness and quality of life in adults with chronic heart failure and reduced ejection fraction.

  Recruiting Cairo University · Cairo, Giza Governorate · NCT07325942

• Intramyocardial umbilical‑cord mesenchymal stem cell injection with CABG for chronic ischemic heart failure

  This trial will test whether injecting umbilical‑cord derived mesenchymal stem cells into the heart at the time of bypass surgery helps people with chronic ischemic heart failure and reduced ejection fraction.

  Recruiting at 2 sites Phase 1/2 Tasly Pharmaceutical Group Co., Ltd · Shanghai, Shanghai Municipality and 3 other locations · NCT07265349

• Temporary heart support with the iVAC 2L device during high-risk coronary procedures

  This trial will try the iVAC 2L temporary heart‑support device during high‑risk PCI to help people with severe coronary artery disease stay hemodynamically stable through the procedure.

  Recruiting National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Moscow · NCT07149714

• Ferric derisomaltose versus no IV iron for people with symptomatic chronic heart failure and iron deficiency

  This trial will test whether giving IV ferric derisomaltose to people with symptomatic chronic heart failure and low iron lowers the chance of hospitalization or death from heart or blood vessel disease.

  Recruiting Phase 3 Pharmacosmos A/S · Pasadena, California · NCT06929806

• AI-driven wearable monitoring for chronic heart failure

  This project will try an AI-driven wearable and mini‑invasive device to see if continuous home monitoring reduces hospital visits and improves health for adults with chronic heart failure.

  Recruiting University of Salerno · Salerno · NCT06909682

• Impact of Empagliflozin on Quality of Life in Heart Failure Patients with Diabetes

  This study is testing if the medication Empagliflozin can improve the quality of life for people with both chronic heart failure and type II diabetes.

  Recruiting Phase 4 Fazaia Ruth Pfau Medical College · Karachi, Sindh · NCT06706791

• Registry of patients with chronic heart failure in Russia

  This study is collecting information from patients with chronic heart failure in Russia to better understand how the condition progresses and is managed over time.

  Recruiting National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Moscow · NCT06683001

• Impact of weight loss on heart function in obese patients with heart failure

  This study is testing if losing weight with the help of a medication and a special diet can improve heart function and quality of life for obese patients with heart failure.

  Recruiting Phase 2/3 Hvidovre University Hospital · Copenhagen · NCT06423599

• Reducing fluid overload in heart failure patients with a new non-invasive system

  This study is testing a new suit that helps people with heart failure and kidney issues sweat out extra fluids to see if it can improve their condition.

  Recruiting at 10 sites AquaPass Medical Ltd. · La Jolla, California and 9 other locations · NCT06360380

• Oral sucrosomial iron's effect on exercise and quality of life in heart failure patients

  This study is testing if a new type of oral iron can help people with heart failure and low iron feel better and exercise more easily compared to a placebo.

  Recruiting Phase 4 Azienda Ospedaliero, Universitaria Pisana · Pisa, Tuscany · NCT06270498

• Heartfelt remote edema monitoring for people with chronic heart failure

  This project will test whether an in-home Heartfelt device that passively detects leg swelling and sends alerts to remote care teams can help people with chronic heart failure who have trouble using other monitoring methods.

  Recruiting at 2 sites Heartfelt Technologies · Little Rock, Arkansas and 2 other locations · NCT06222099

• Exercise training effects on frailty and fall risk in chronic heart failure patients

  This study is testing if exercise training can help people with chronic heart failure feel stronger and reduce their risk of falling.

  Recruiting Aristotle University Of Thessaloniki · Thessaloniki, Thermi · NCT06036615

• Yoga's effect on heart failure patients' quality of life

  This study tests if yoga can improve the quality of life for people with chronic heart failure compared to those who participate in storytelling workshops.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06019169

• Promoting physical activity in patients with COPD and heart failure

  This study is testing if a new program called Mindful Steps can help people with COPD and heart failure be more active by tracking their daily steps for a year.

  Recruiting at 2 sites Beth Israel Deaconess Medical Center · Boston, Massachusetts and 1 other locations · NCT05934565

• Examining iron deficiency treatment in heart failure patients

  This study tests if treating iron deficiency with a specific medication can help improve the quality of life and daily functioning for people with heart failure.

  Recruiting Phase 4 Tomsk National Research Medical Center of the Russian Academy of Sciences · Tomsk · NCT05793996

• Observing the safety of vericiguat in Japanese patients with chronic heart failure

  This study is testing how safe the drug vericiguat is for Japanese patients with chronic heart failure as they use it in their regular treatment.

  Recruiting Bayer · Multiple Locations, Many Locations · NCT05666518

• Evaluating congestion in chronic heart failure with preserved ejection fraction

  This study is testing different ways to check for fluid buildup in patients with chronic heart failure who have normal heart function to see how it affects their health and hospital visits.

  Recruiting Central Hospital, Nancy, France · Vandœuvre-lès-Nancy · NCT05097898

• Evaluating congestion in chronic heart failure patients

  This study is testing different ways to measure congestion in people with chronic heart failure to see how it relates to their risk of serious health issues.

  Recruiting Central Hospital, Nancy, France · Vandœuvre-lès-Nancy · NCT05089162

• Evaluating congestion in chronic heart failure patients

  This study is trying to find out if certain signs of congestion in people with chronic heart failure can help predict their risk of being hospitalized or dying within two years.

  Recruiting Central Hospital, Nancy, France · Vandœuvre-lès-Nancy and 1 other locations · NCT05089149

• Effects of exercise and cognitive training on brain health in heart failure patients

  This study is testing if combining exercise with brain training can help improve thinking skills and brain health in older adults with chronic heart failure.

  Recruiting Montreal Heart Institute · Montreal, Quebec · NCT04970888

• Investigating biomarkers to predict chronic heart failure in older patients with type 2 diabetes

  This study is trying to find specific markers in the blood that can help predict if older people with type 2 diabetes will develop chronic heart failure, so they can be monitored and treated early.

  Recruiting Regionshospital Nordjylland · Hjørring · NCT04941794

• Non-invasive ventilation versus high-flow oxygen: effects on heart function

  This trial tests whether high-flow oxygen or non-invasive ventilation better lowers pulmonary artery pressure in adults with chronic heart failure and reduced ejection fraction after cardiac surgery.

  Recruiting University Hospital, Rouen · Rouen · NCT04471129

• Virtual Heart Failure Clinic for Patient Self-Management

  This study is testing if a virtual Heart Failure Clinic using a special sensor to monitor heart health can help people manage their condition better than regular care.

  Recruiting Montreal Heart Institute · Montreal, Quebec · NCT04441203

• Assessing the impact of comorbidities on postoperative complications.

  This study looks at how having other health issues affects the chances of complications after abdominal surgery to help doctors better understand and manage risks for their patients.

  Recruiting at 37 sites Russian Federation of Anesthesiologists and Reanimatologists · Arkhangelsk and 37 other locations · NCT03945968

NIH-funded research (19)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Optogenetic silence to reduce harmful heart rhythms via kidney nerves in chronic heart failure

  A new approach uses light to quiet kidney-nerve signals to lower dangerous heart rhythms in people with chronic heart failure.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11411192

• Stellate Gland Nrf2 Signaling and Heart–Nerve Interactions in Chronic Heart Failure

  A study in people is not required; instead, this grant focuses on how the brain and nerves control heart problems in chronic heart failure through a key protective pathway called Nrf2.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11402729

• New immune-based inhibitors to modulate T cells in chronic heart failure

  A patient-facing overview of a study exploring how immune cells, especially CD4+ T-cells, influence heart healing and worsening of heart failure after a heart attack, with the goal of finding targeted ways to improve heart function.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11395367

• Cell-directed Immunomodulation to Help with LVAD Surgery in Chronic Heart Failure

  A patient-friendly approach tests an immunomodulation device to improve heart and kidney function in people with advanced heart failure who are awaiting LVAD implantation but currently ineligible.

  NIH research Innovative Biotherapies, INC. · Ann Arbor, United States · NIH-11361118

• Bifidobacterium gut microbiome and heart failure connection

  A doctor-scientist at Stanford is studying how the gut bacteria, especially Bifidobacterium, relate to heart failure with reduced ejection fraction to uncover new ways to prevent or treat the condition.

  NIH research Stanford University · Stanford, United States · NIH-11332441

• Mobile app and personalized text messages to help people manage chronic heart failure

  This project combines smartphone apps, connected devices, and tailored text messages to help people with chronic heart failure stick to medications, monitor symptoms, and stay active.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11326341

• B cells triggering sex-specific heart messages after injury

  This grant explores how B cells presenting antigens influence heart and spleen communication after heart injury, with a focus on differences between males and females.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11296301

• Why heart nerves become overactive in chronic heart failure

  This project looks at how support cells and immune cells near heart nerves may cause too much nerve activity that leads to dangerous heart rhythms in people with advanced heart failure.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11237983

• A clearer symptom questionnaire for chronic heart failure

  This project checks whether a new questionnaire clearly captures symptoms experienced by people living with chronic heart failure.

  NIH research Critical Path Institute · Tucson, United States · NIH-11181657

• Nrf2 signaling in the heart's sympathetic nerves in chronic heart failure

  Testing whether boosting the antioxidant regulator Nrf2 in the nerves that control the heart can calm overactive nerve signals and reduce dangerous heart rhythms in chronic heart failure.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11180508

• New drugs to control T‑cell activity in long‑term heart failure

  New medicines aim to calm specific immune T‑cells to protect the heart in people with chronic heart failure after a heart attack.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11138696

• Light-controlled targeting of kidney nerves to lower dangerous heart rhythms in heart failure

  This project uses light-sensitive tools to turn off specific kidney-related nerve cells to try to reduce dangerous heart rhythms in people with chronic heart failure.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11121107

• Evaluating a new scale to measure symptoms of chronic heart failure.

  This study is working on a new tool to help understand the symptoms of chronic heart failure, like breathlessness and fatigue, and it’s looking for patients to share their experiences so we can make sure it’s really helpful for improving treatment.

  NIH research Critical Path Institute · Tucson, United States · NIH-11087976

• A new device to help severe heart failure patients prepare for an artificial heart pump

  This project is testing a special device to help very sick heart failure patients become strong enough for a life-saving artificial heart pump.

  NIH research Innovative Biotherapies, INC. · Ann Arbor, United States · NIH-11078730

• A mobile health app and text messaging program to help patients manage chronic heart failure

  This study is testing a new mobile app and text message support to help people with chronic heart failure take better care of themselves by reminding them to stick to their medications, diets, and monitor their symptoms more easily.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11065539

• Investigating how nerve signaling affects heart function in chronic heart failure

  This study is looking at how a protein called Nrf2 affects nerve signals that help your heart work properly, especially for people with chronic heart failure, to find new ways to improve heart health after a heart attack.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-10990834

• Using light to control nerve activity for treating heart rhythm problems in heart failure patients

  This study is looking at a new way to help people with chronic heart failure by using light to calm down certain nerves in the kidneys, which could help prevent dangerous heart rhythms.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-10914944

• New treatments to improve heart healing after a heart attack

  This study is looking at how certain immune cells in your body can help your heart heal after a heart attack, with the goal of finding better ways to support recovery and improve heart function.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-10878724

• Investigating how Bifidobacterium in the gut affects chronic heart failure

  This study is looking at how certain gut bacteria might affect people with chronic heart failure, and it aims to find out if changes in these bacteria can help us understand the condition better and improve treatments, so patients may be asked to share some blood samples and health information.

  NIH research Stanford University · Stanford, United States · NIH-10807596

Related topics

Quick answers

How many Chronic Heart Failure clinical trials are recruiting right now?

30, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (6 trials), France (5 trials), Russia (4 trials), Canada (2 trials), Denmark (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 3: 1, Phase 1: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →