A clearer symptom questionnaire for chronic heart failure
Official title: Psychometric Analyses and Quantitative Study Report for Qualification of the Chronic Heart Failure Symptom Scale (CHF-SS) (DDT COA #000112)
Funded at Critical Path Institute · NIH-11181657 · Data updated 2026-11-12
This project checks whether a new questionnaire clearly captures symptoms experienced by people living with chronic heart failure.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Critical Path Institute NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $248,278 |
| NIH project number | 5U01FD008423-02 |
| Project ID | NIH-11181657 on NIH RePORTER |
Who could benefit from this research
✓Could help
People living with chronic heart failure who experience symptoms such as shortness of breath, fatigue, swelling, or sleep problems are the intended participants.
✕Less likely to help
People without chronic heart failure or those only experiencing brief, acute heart issues are unlikely to benefit directly from this project.
What this research studies
If you have chronic heart failure, you might be asked to complete the CHF-SS questionnaire and possibly take part in brief interviews or online surveys. The team will combine patient responses with existing clinical trial and registry data and apply statistical (psychometric) tests to see which questions work well. They will look at how consistent the answers are, whether the questions match real symptoms, and whether the measure can detect meaningful change over time. The results will be compiled into a quantitative report to support using the questionnaire in drug development.
Why it matters
Potential benefit: If successful, the CHF-SS could provide a trusted way to capture symptoms that matter to patients and help guide better treatments and trials.
How similar studies have gone: Other heart-failure patient-reported questionnaires have been used in trials, but this effort follows newer FDA guidance and aims to produce stronger, qualification-ready evidence.
Where this research is happening
-
Critical Path Institute
Tucson, United States Active
Researchers
- Principal investigator: Mattera, Maria — Critical Path Institute
- Study coordinator: Mattera, Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.