Low- versus high-volume high-intensity interval training for people with chronic heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with stable chronic heart failure and reduced ejection fraction (EF <40) will be enrolled and placed into one of three groups: low-volume HIIT, high-volume HIIT, or standard medical treatment. Participants in the exercise groups will follow supervised high-intensity interval training programs with different total training volumes while continuing usual medical care. Functional capacity and quality of life will be measured before and after the intervention to compare effects across groups. Safety monitoring will follow contemporary exercise contraindication guidance to exclude patients at high risk for adverse events.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Chronic stable heart failure patient with reduced ejection fraction (EF \<40)
2. Age Above 18 years old
3. Both males and females
4. The ability to provide informed consent

Exclusion Criteria:

1. Based on the Scientific Statement from the American Heart Association: contraindications for exercise Testing and Training. (Fletcher et al., 2013)

   1. Acute myocardial infarction (MI), within 2 days
   2. Ongoing unstable angina
   3. Uncontrolled cardiac tachy or brady arrhythmia with hemodynamic compromise
   4. Active endocarditis
   5. Symptomatic severe aortic stenosis
   6. Decompensated heart failure
   7. Acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis
   8. Acute myocarditis or pericarditis
   9. Acute aortic dissection
   10. Physical disability that precludes safe and adequate testing or training
   11. Known obstructive left main coronary artery stenosis
   12. Hypertrophic obstructive cardiomyopathy with severe resting gradient
   13. Recent stroke or transient ischemic attack
   14. Mental impairment with limited ability to cooperate
   15. Resting hypertension with systolic or diastolic blood pressures \>200/110 mmHg
   16. Uncorrected medical conditions, such as significant anemia, important electrolyte imbalance, and hyperthyroidism
2. Acute decompensated heart failure NYHA class IV

Where it's running

• Cairo University
  Cairo, Giza Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Aya I Elshenawy
• Email: dr.aya_ebrahime@yahoo.com
• Phone: +01098811085

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.