Bifidobacterium gut microbiome and heart failure connection
Official title: The Role of the Bifidobacterium Gut Microbiome Guild in Pathophysiology of Chronic Heart Failure with Reduced Ejection Fraction
Funded at Stanford University · NIH-11332441 · Data updated 2026-11-12
A doctor-scientist at Stanford is studying how the gut bacteria, especially Bifidobacterium, relate to heart failure with reduced ejection fraction to uncover new ways to prevent or treat the condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $165,996 |
| NIH project number | 5K08HL164881-03 |
| Project ID | NIH-11332441 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21+ with chronic heart failure with reduced ejection fraction who have been or could be enrolled in related longitudinal cohorts.
✕Less likely to help
Patients without heart failure or those not connected to the gut-immune interaction framework may see no direct benefit.
What this research studies
This project looks at how the gut microbiome interacts with chronic heart failure over time, using advanced multi-omics analyses and clinical data from 60 adults. The research will track changes in gut bacteria and the body’s immune signals to see how they relate to heart failure severity and outcomes. The goal is to translate these findings into precision medicine approaches that could guide future therapies and prevention strategies.
Why it matters
Potential benefit: If successful, the work could lead to personalized gut-health-based strategies to slow heart failure progression.
How similar studies have gone: Previous research has begun to link gut bacteria to cardiovascular health, with growing evidence of associations between microbiome shifts and heart failure outcomes.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Mamic, Petra — Stanford University
- Study coordinator: Mamic, Petra
Related research
Other NIH-funded projects on the same topics.
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Investigating how Bifidobacterium in the gut affects chronic heart failure
This study is looking at how certain gut bacteria might affect people with chronic heart failure, and it aims to find out if changes in these bacteria can help us understand the condition better and improve treatments, so patients may be asked to share some blood samples and health information.
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Stellate Gland Nrf2 Signaling and Heart–Nerve Interactions in Chronic Heart Failure
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-
New immune-based inhibitors to modulate T cells in chronic heart failure
A patient-facing overview of a study exploring how immune cells, especially CD4+ T-cells, influence heart healing and worsening of heart failure after a heart attack, with the goal of finding targeted ways to improve heart function.
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Cell-directed Immunomodulation to Help with LVAD Surgery in Chronic Heart Failure
A patient-friendly approach tests an immunomodulation device to improve heart and kidney function in people with advanced heart failure who are awaiting LVAD implantation but currently ineligible.
-
Mobile app and personalized text messages to help people manage chronic heart failure
This project combines smartphone apps, connected devices, and tailored text messages to help people with chronic heart failure stick to medications, monitor symptoms, and stay active.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.