Condition

Heart Failure With Reduced Ejection Fraction (HFrEF) clinical trials and research

• 14Clinical trials
• 13Countries

Newest Heart Failure With Reduced Ejection Fraction (HFrEF) clinical trials

All recruiting trials (14)

• Atrial Shunt to Help Heart Failure With Reduced Ejection Fraction

  This study tests whether an atrial shunt implanted after heart catheterization helps people with HFrEF when added to standard heart failure therapy.

  Recruiting Phase 2/3 Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT07820410

• Achieving Optimal Medical Therapy Through Transcatheter Mitral Repair in HFrEF

  This trial tests whether early transcatheter edge-to-edge repair (M-TEER) helps patients with HFrEF and secondary MR reach guideline-directed medical therapy faster and more completely, and whether that improves quality of life and outcomes.

  Recruiting University Medical Center Mainz · Mainz, Rhineland-Palatine · NCT07758023

• CRD-4730 for heart failure with reduced ejection fraction

  This trial tests CRD-4730 versus placebo to see if it helps adults with HFrEF who are already on standard heart failure therapy.

  Recruiting at 2 sites Phase 2 Cardurion Pharmaceuticals, Inc. · Pasadena, California and 1 other locations · NCT07750873

• Olive oil supplementation during cardiac rehab for heart failure with reduced ejection fraction

  This study tests whether adding extra-virgin olive oil during a cardiac rehabilitation program is doable and helpful for people with HFrEF.

  Recruiting Old Dominion University · Norfolk, Virginia · NCT07644806

• Remote-guided medication up-titration for people with reduced ejection fraction heart failure

  This trial will see if telemedicine follow-up helps clinicians start and increase guideline-recommended heart failure medicines faster and more completely in adults with newly diagnosed HFrEF.

  Recruiting Azienda Unita Sanitaria Locale di Piacenza · Piacenza · NCT07518030

• Vericiguat for right‑ventricular function and heart remodeling in HFrEF

  This study will test whether adding vericiguat to usual heart‑failure treatment helps adults with stable HFrEF improve right‑ventricular function and heart remodeling over 12 months.

  Recruiting at 4 sites Phase 4 University Medical Centre Ljubljana · Izola and 3 other locations · NCT07405944

• Nerve ablation for heart failure with reduced ejection fraction using the right greater splanchnic nerve

  This early-stage, catheter-based test looks at whether ablating the right greater splanchnic nerve can help people 40 and older with HFrEF and is done in a randomized, sham-controlled setup.

  Recruiting at 7 sites Axon Therapies, Inc. · Prague and 8 other locations · NCT07403058

• Intensive GDMT optimization for women after heart failure hospitalization

  This study tests whether rapidly increasing and closely monitoring heart failure meds in women after hospitalization can reduce death or readmission within a year.

  Recruiting Phase 4 IRCCS Policlinico S. Donato · San Donato Milanese, MILANO and 11 other locations · NCT07295522

• Once-daily versus twice-daily ramipril for kidney health in CKD patients with reduced ejection fraction heart failure

  This trial tests whether taking ramipril once a day or split into twice-daily doses better protects kidney function in adults who have chronic kidney disease and heart failure with reduced ejection fraction.

  Recruiting Phase 4 Universitas Sebelas Maret · Kartasura, Central Java · NCT07259512

• SmartSignalHF remote monitoring for people with implanted ICD or CRT‑D and heart failure

  This tests whether SmartSignalHF remote monitoring for people with implanted ICD or CRT‑D and chronic heart failure can reduce deaths and heart failure hospital visits over 12 months compared with standard remote monitoring.

  Recruiting Implicity · Paris · NCT07247032

• AI analysis of ECGs to detect structural heart disease

  This project will test whether AI can read traditional and wearable ECGs to find undiagnosed valve disease, pulmonary hypertension, and heart failure in adults.

  Recruiting at 6 sites Imperial College London · Bristol and 5 other locations · NCT07057466

• Carvedilol versus metoprolol succinate in people with heart failure and an implanted defibrillator

  This study will test whether switching from metoprolol succinate to carvedilol reduces ICD therapies, heart-related hospitalizations, or cardiovascular death in adults with HFrEF and an ICD.

  Recruiting at 13 sites Phase 4 University of Rochester · Scottsdale, Arizona and 12 other locations · NCT06964464

• AI-driven wearable monitoring for chronic heart failure

  This project will try an AI-driven wearable and mini‑invasive device to see if continuous home monitoring reduces hospital visits and improves health for adults with chronic heart failure.

  Recruiting University of Salerno · Salerno · NCT06909682

• Investigating heart function improvement in patients with specific heart pacing methods

  This study tests whether a new heart pacing method can help people with heart failure feel better compared to the standard pacing method.

  Recruiting University Hospital of Patras · Pátrai, Greece · NCT06689111

Related topics

Quick answers

How many Heart Failure With Reduced Ejection Fraction (HFrEF) clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (3 trials), Italy (3 trials), United Kingdom (2 trials), Greece (1 trial), Czechia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 2: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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