Investigating how nerve signaling affects heart function in chronic heart failure
Official title: Stellate Ganglia Nrf2 Signaling and Enhanced Cardiac Sympathetic Tone in Chronic Heart Failure
Funded at University of Nebraska Medical Center · NIH-10990834 · Data updated 2026-11-12
This study is looking at how a protein called Nrf2 affects nerve signals that help your heart work properly, especially for people with chronic heart failure, to find new ways to improve heart health after a heart attack.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $741,512 |
| NIH project number | 1R01HL172029-01A1 |
| Project ID | NIH-10990834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic heart failure, particularly those who have experienced a myocardial infarction.
✕Less likely to help
Patients without chronic heart failure or those with other unrelated cardiac conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific protein, Nrf2, in nerve signaling related to heart function in patients with chronic heart failure. It examines how oxidative stress and inflammation in the nervous system can impact heart activity and potentially lead to arrhythmias. By studying changes in nerve signaling after a heart attack, the research aims to identify new therapeutic targets that could improve heart health. The approach involves both genetic and biochemical analyses in animal models to uncover the underlying mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce the risk of arrhythmias in patients with chronic heart failure.
How similar studies have gone: Previous studies have shown promising results in understanding the role of Nrf2 in heart function, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Wang, Hanjun — University of Nebraska Medical Center
- Study coordinator: Wang, Hanjun
Related research
Other NIH-funded projects on the same topics.
-
Optogenetic silence to reduce harmful heart rhythms via kidney nerves in chronic heart failure
A new approach uses light to quiet kidney-nerve signals to lower dangerous heart rhythms in people with chronic heart failure.
-
Stellate Gland Nrf2 Signaling and Heart–Nerve Interactions in Chronic Heart Failure
A study in people is not required; instead, this grant focuses on how the brain and nerves control heart problems in chronic heart failure through a key protective pathway called Nrf2.
-
New immune-based inhibitors to modulate T cells in chronic heart failure
A patient-facing overview of a study exploring how immune cells, especially CD4+ T-cells, influence heart healing and worsening of heart failure after a heart attack, with the goal of finding targeted ways to improve heart function.
-
Cell-directed Immunomodulation to Help with LVAD Surgery in Chronic Heart Failure
A patient-friendly approach tests an immunomodulation device to improve heart and kidney function in people with advanced heart failure who are awaiting LVAD implantation but currently ineligible.
-
Bifidobacterium gut microbiome and heart failure connection
A doctor-scientist at Stanford is studying how the gut bacteria, especially Bifidobacterium, relate to heart failure with reduced ejection fraction to uncover new ways to prevent or treat the condition.
-
Mobile app and personalized text messages to help people manage chronic heart failure
This project combines smartphone apps, connected devices, and tailored text messages to help people with chronic heart failure stick to medications, monitor symptoms, and stay active.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.