Investigating how nerve signaling affects heart function in chronic heart failure
Stellate Ganglia Nrf2 Signaling and Enhanced Cardiac Sympathetic Tone in Chronic Heart Failure
This study is looking at how a protein called Nrf2 affects nerve signals that help your heart work properly, especially for people with chronic heart failure, to find new ways to improve heart health after a heart attack.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10990834 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein, Nrf2, in nerve signaling related to heart function in patients with chronic heart failure. It examines how oxidative stress and inflammation in the nervous system can impact heart activity and potentially lead to arrhythmias. By studying changes in nerve signaling after a heart attack, the research aims to identify new therapeutic targets that could improve heart health. The approach involves both genetic and biochemical analyses in animal models to uncover the underlying mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic heart failure, particularly those who have experienced a myocardial infarction.
Not a fit: Patients without chronic heart failure or those with other unrelated cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce the risk of arrhythmias in patients with chronic heart failure.
How similar studies have performed: Previous studies have shown promising results in understanding the role of Nrf2 in heart function, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Wang, Hanjun — University of Nebraska Medical Center
- Study coordinator: Wang, Hanjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.