Investigating how Bifidobacterium in the gut affects chronic heart failure
Official title: The Role of the Bifidobacterium Gut Microbiome Guild in Pathophysiology of Chronic Heart Failure with Reduced Ejection Fraction
Funded at Stanford University · NIH-10807596 · Data updated 2026-11-12
This study is looking at how certain gut bacteria might affect people with chronic heart failure, and it aims to find out if changes in these bacteria can help us understand the condition better and improve treatments, so patients may be asked to share some blood samples and health information.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $165,996 |
| NIH project number | 1K08HL164881-01A1 |
| Project ID | NIH-10807596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with chronic heart failure with reduced ejection fraction.
✕Less likely to help
Patients without chronic heart failure or those with other types of heart failure may not benefit from this research.
What this research studies
This research focuses on understanding the interactions between the gut microbiome, specifically Bifidobacterium, and chronic heart failure with reduced ejection fraction. By analyzing data from patients with this condition, the research aims to uncover how changes in gut bacteria relate to heart failure severity and progression. The study will utilize advanced techniques to assess the microbiome and immune responses over time, potentially leading to new treatment strategies. Patients may be involved in providing blood samples and other clinical data to support these findings.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve heart failure outcomes by targeting gut microbiome health.
How similar studies have gone: Previous research has shown promising results in understanding the gut microbiome's role in various health conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Mamic, Petra — Stanford University
- Study coordinator: Mamic, Petra
Related research
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-
Bifidobacterium gut microbiome and heart failure connection
A doctor-scientist at Stanford is studying how the gut bacteria, especially Bifidobacterium, relate to heart failure with reduced ejection fraction to uncover new ways to prevent or treat the condition.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.