Evaluating congestion in chronic heart failure patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients with chronic heart failure and reduced ejection fraction, aiming to identify various congestion markers through clinical examinations, laboratory tests, and ultrasound evaluations. By quantifying these markers during consultations or day hospitalizations, the study seeks to correlate them with the risk of all-cause mortality, hospitalizations for acute heart failure, or the need for intravenous diuretics. The approach is integrative, combining multiple modalities to provide a comprehensive assessment of congestion in these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with chronic acute heart failure with reduced ventricular ejection fraction admitted in hospital for scheduled day hospitalization or in consultation
* Patient with altered (left ventricular ejection fraction \<40%) and moderately altered (left ventricular ejection fraction between 40 and 50%) left ventricular ejection fraction
* Age ≥18 years
* Patients having received complete information regarding the study design and having signed their informed consent form.
* Patient affiliated to or beneficiary of a social security scheme.

Exclusion Criteria:

* Comorbidity for which the life expectancy is ≤ 3 months
* Dialysis patient (peritoneal dialysis or hemodialysis) or patients with glomerular filtration rate \<15 ml/min/m2 at inclusion.
* History of lobectomy or pneumonectomy lung surgery
* Severe pulmonary or pleural pathology preventing reliable acquisition of lung ultrasound images: severe emphysema, chronic pleurisy, pulmonary fibrosis, etc.
* Pregnant woman, parturient or nursing mother
* Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
* Adult person who is unable to give consent
* Person deprived of liberty by a judicial or administrative decision,
* Person subject to psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1 of the Public Health Code.

Where it's running

• CHRU de Nancy
  Vandœuvre-lès-Nancy, France Recruiting

Study contacts

• Study coordinator: Nicolas GIRERD, MD, PhD
• Email: n.girerd@chru-nancy.fr
• Phone: 0033383157322

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.