Voice-based detection of heart failure deterioration using Noah Labs Vox
Official title: Voice-based Outcome Identification and Clinical Evaluation in Heart Failure
Run by Noah Labs · NCT07870395 · Data updated 2026-11-12
This study tests whether a voice-analysis app can flag worsening heart failure in adults by comparing its alerts to standard weight-based monitoring.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 22 Years and up |
| Sex | All |
| Enrollment | 450 (estimated) |
| Sponsor | Noah Labs Industry-sponsored |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | October 15, 2026 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | October 27, 2026 |
| Trial ID | NCT07870395 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 22 and older with a diagnosis of Stage C heart failure, including a recent DHF event within the prior 180 days.
✕Probably not a fit
Patients without worsening HF signals detectable by voice patterns or who have reliable alternative monitoring without voice data may see no benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
VOICE-HF is a prospective, multicenter, single-arm observational study that evaluates the Noah Labs Vox algorithm using an independent dataset. Participants will provide daily smartphone voice recordings for 180 days to see if the software can identify signs of worsening heart failure before a decompensation event. The study compares the voice-based approach to conventional remote monitoring rules to understand relative performance, safety, and potential clinical usefulness. An adjudicated clinical events committee will determine DHF events to contextualize the algorithm’s signals. Approximately 450 adults with Stage C heart failure of any etiology and a full range of LVEF will be enrolled at Brigham and Women's Hospital and monitored remotely.
Why it matters
Potential benefit: If successful, the voice-based tool could enable earlier detection of DHF and timely intervention to prevent hospitalizations.
How similar studies have gone: Previous work in digital health supports the concept that voice signals can reflect cardiopulmonary status, but this exact approach is being evaluated in this trial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥22 * HF diagnosis (Stage C) * DHF event within prior 180 days Exclusion Criteria: * Monitoring with implantable volume or pressure monitoring devices, or * Planned cardiac surgery or major intervention (e.g., LVAD or transplant), or * Otherwise inability or unwillingness to comply with study procedures.
Where it's running
-
Brigham and Women's Hospital
Boston, Massachusetts, United States Recruiting
Study contacts
- Study coordinator: Leonhard Riehle MD, MD
- Email: leonhard.riehle@noah-labs.com
- Phone: +49 171 5547970
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.