How immune cells interact with nerve cells in chemotherapy-related nerve damage
Neuron-macrophage interactions in models of chemotherapy-induced peripheral neuropathy
['FUNDING_R21'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10673851
This study is looking at how immune cells and pain-sensing nerve cells work together in people who have pain from chemotherapy, to find new ways to help manage that pain.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10673851 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between immune cells called macrophages and pain-sensing nerve cells in patients suffering from chemotherapy-induced peripheral neuropathy (CIPN). The study aims to understand how inflammation caused by chemotherapy affects these interactions and contributes to chronic pain. By using models from fruit flies and mice, researchers will explore how changing the activation state of macrophages might help prevent nerve hypersensitivity. This could lead to new strategies for managing pain in patients affected by CIPN.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced chemotherapy-induced peripheral neuropathy and suffer from chronic pain as a result.
Not a fit: Patients who have not undergone chemotherapy or do not experience peripheral neuropathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate chronic pain for patients suffering from chemotherapy-induced peripheral neuropathy.
How similar studies have performed: While the specific approach of investigating neuron-macrophage interactions in CIPN is novel, related studies have shown promise in understanding immune cell roles in nerve damage and pain.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRUEBER, WESLEY B — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: GRUEBER, WESLEY B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.