New treatments for nerve pain caused by chemotherapy
Official title: Antagonists of CRMP2 Phosphorylation for Chemotherapy-Induced Peripheral Neuropathy
Funded at University of Florida · NIH-11126912 · Data updated 2026-11-12
This study is looking for new medications to help manage nerve pain that some people experience after chemotherapy, focusing on a protein called CRMP2, with the hope of finding safer treatments that don't involve opioids.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 15, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $902,822 |
| NIH project number | 7R61NS126026-02 |
| Project ID | NIH-11126912 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients experiencing neuropathic pain as a result of chemotherapy treatment.
✕Less likely to help
Patients who do not have neuropathic pain or those who have not undergone chemotherapy may not benefit from this research.
What this research studies
This research focuses on identifying new medications to manage neuropathic pain, particularly pain that can occur after chemotherapy. The team is investigating a specific protein, CRMP2, which is linked to nerve injury and pain development. By screening a large number of compounds, they aim to find effective treatments that target this protein and improve pain management without relying on opioids. Patients may benefit from innovative therapies that address their pain more effectively and safely.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted medications that provide relief from chemotherapy-induced nerve pain without the risks associated with opioids.
How similar studies have gone: Other research has shown promise in targeting specific proteins for pain management, suggesting that this approach could be effective.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Khanna, Rajesh — University of Florida
- Study coordinator: Khanna, Rajesh
Related research
Other NIH-funded projects on the same topics.
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Non-invasive, microscopic biomarkers to detect CIPN in chemotherapy patients
This grant aims to develop a non-invasive imaging method to measure nerve changes in patients undergoing chemotherapy to better understand and monitor chemotherapy-induced peripheral neuropathy (CIPN).
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Longitudinal study of how body-sense relates to chemotherapy nerve damage
This study follows people with breast or gastrointestinal cancer and healthy controls to see if brain processing of body sensations contributes to chemotherapy-induced nerve damage.
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A new screen for chemotherapy-related nerve problems in young children
A clinician-scientist at Yale is developing a child-friendly survey to quickly screen for nerve-related side effects from cancer treatment in kids from birth to age 5.
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How the immune system’s CD4+ T cells in women might prevent chemotherapy-related nerve pain
A study in mice explores whether female immune cells in nerve tissue can lessen pain from chemotherapy, with potential implications for preventing CIPN in women.
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Axonal transport and chemotherapy-related nerve pain
This grant studies why certain cancer patients develop painful nerve damage from chemotherapy and explores ways to prevent or treat it.
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Remote monitoring and nurse follow-up to manage chemotherapy-induced peripheral neuropathy
A program uses symptom reporting tools with nurse follow-up to reduce and better manage chemotherapy-induced neuropathy for cancer survivors, during and after treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.