New treatments for nerve pain caused by chemotherapy
Antagonists of CRMP2 Phosphorylation for Chemotherapy-Induced Peripheral Neuropathy
This study is looking for new medications to help manage nerve pain that some people experience after chemotherapy, focusing on a protein called CRMP2, with the hope of finding safer treatments that don't involve opioids.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11126912 on NIH RePORTER |
What this research studies
This research focuses on identifying new medications to manage neuropathic pain, particularly pain that can occur after chemotherapy. The team is investigating a specific protein, CRMP2, which is linked to nerve injury and pain development. By screening a large number of compounds, they aim to find effective treatments that target this protein and improve pain management without relying on opioids. Patients may benefit from innovative therapies that address their pain more effectively and safely.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients experiencing neuropathic pain as a result of chemotherapy treatment.
Not a fit: Patients who do not have neuropathic pain or those who have not undergone chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted medications that provide relief from chemotherapy-induced nerve pain without the risks associated with opioids.
How similar studies have performed: Other research has shown promise in targeting specific proteins for pain management, suggesting that this approach could be effective.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Khanna, Rajesh — University of Florida
- Study coordinator: Khanna, Rajesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.