Predicting nerve damage from chemotherapy in cancer patients
Official title: Clinical biomarker for early prediction of chemotherapy-induced peripheral neuropathy
Funded at Newventureiq, LLC · NIH-10604018 · Data updated 2026-11-12
This study is looking for a way to predict if patients will experience painful nerve issues from the cancer drug oxaliplatin by tracking their sensitivity to cold through a mobile app, making it easier to personalize treatments and help improve their comfort during chemotherapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Newventureiq, LLC NIH-funded |
| Lab location | 1 site (St. Louis, UNITED STATES) |
| Project start | September 19, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $403,240 |
| NIH project number | 1R41CA277875-01 |
| Project ID | NIH-10604018 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients receiving oxaliplatin-based chemotherapy for colorectal cancer.
✕Less likely to help
Patients not undergoing chemotherapy or those receiving treatments other than oxaliplatin may not benefit from this research.
What this research studies
This research focuses on developing a biomarker to predict chemotherapy-induced peripheral neuropathy (CIPN), a painful side effect of the cancer drug oxaliplatin. By using a mobile health system, the study aims to collect and analyze patient-reported data on cold sensitivity, which may indicate the risk of developing CIPN. The approach is non-invasive and designed to be easily implemented, even in low-resource settings. If successful, this research could help tailor chemotherapy treatments to minimize nerve damage and improve patient quality of life.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of painful nerve damage in cancer patients undergoing chemotherapy.
How similar studies have gone: Preliminary studies using similar predictive methods have shown promising results, indicating potential for success in this approach.
Where this research is happening
-
Newventureiq, LLC
St. Louis, United States Active
Researchers
- Principal investigator: Haroutounian, Simon — Newventureiq, LLC
- Study coordinator: Haroutounian, Simon
Related research
Other NIH-funded projects on the same topics.
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Non-invasive, microscopic biomarkers to detect CIPN in chemotherapy patients
This grant aims to develop a non-invasive imaging method to measure nerve changes in patients undergoing chemotherapy to better understand and monitor chemotherapy-induced peripheral neuropathy (CIPN).
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Longitudinal study of how body-sense relates to chemotherapy nerve damage
This study follows people with breast or gastrointestinal cancer and healthy controls to see if brain processing of body sensations contributes to chemotherapy-induced nerve damage.
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A new screen for chemotherapy-related nerve problems in young children
A clinician-scientist at Yale is developing a child-friendly survey to quickly screen for nerve-related side effects from cancer treatment in kids from birth to age 5.
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How the immune system’s CD4+ T cells in women might prevent chemotherapy-related nerve pain
A study in mice explores whether female immune cells in nerve tissue can lessen pain from chemotherapy, with potential implications for preventing CIPN in women.
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Axonal transport and chemotherapy-related nerve pain
This grant studies why certain cancer patients develop painful nerve damage from chemotherapy and explores ways to prevent or treat it.
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Remote monitoring and nurse follow-up to manage chemotherapy-induced peripheral neuropathy
A program uses symptom reporting tools with nurse follow-up to reduce and better manage chemotherapy-induced neuropathy for cancer survivors, during and after treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.