Understanding how body sensations affect nerve pain from chemotherapy
Longitudinal assessment of the role of interoception in chemotherapy-induced peripheral neuropathy (CIPN) along the cancer chemotherapy continuum
This study is looking at how chemotherapy affects nerve pain and how your brain senses these feelings, and it's for people with breast or gastrointestinal cancer who are getting treatment, as well as some healthy individuals for comparison.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10800311 on NIH RePORTER |
What this research studies
This research investigates the impact of chemotherapy on nerve pain, specifically focusing on how the brain processes sensations from the body, known as interoception. It involves observing 120 patients with breast or gastrointestinal cancer receiving specific chemotherapy treatments, alongside 60 healthy individuals for comparison. Participants will undergo assessments before, shortly after, and six months after chemotherapy, which will include brain imaging and evaluations of nerve function and symptoms. The goal is to uncover the underlying mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) to improve patient care.
Who could benefit from this research
Good fit: Ideal candidates are patients diagnosed with breast or gastrointestinal cancer who are scheduled to receive taxane or platinum-based chemotherapy.
Not a fit: Patients who are not undergoing chemotherapy or those with other unrelated medical conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of nerve pain caused by chemotherapy, potentially improving the quality of life for cancer patients.
How similar studies have performed: While the specific focus on interoception in CIPN is relatively novel, previous research has shown that understanding brain-body interactions can lead to advancements in managing chemotherapy side effects.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Kleckner, Ian Robert — University of Maryland Baltimore
- Study coordinator: Kleckner, Ian Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.