A new screen for chemotherapy-related nerve problems in young children
Official title: Development of a novel survey to screen for chemotherapy-induced peripheral neuropathy in young children
Funded at Yale University · NIH-11381211 · Data updated 2026-11-12
A clinician-scientist at Yale is developing a child-friendly survey to quickly screen for nerve-related side effects from cancer treatment in kids from birth to age 5.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $255,225 |
| NIH project number | 5K08CA286835-03 |
| Project ID | NIH-11381211 on NIH RePORTER |
Who could benefit from this research
✓Could help
Young children with cancer who are undergoing treatment or who have received treatment and may experience CIPN.
✕Less likely to help
Children without exposure to neurotoxic chemotherapy or without neuropathic symptoms may derive limited direct benefit from this specific screening tool.
What this research studies
This project aims to create and validate an easy-to-use survey to detect chemotherapy-induced peripheral neuropathy (CIPN) in young children who have survived or are undergoing cancer treatment. The work will combine qualitative methods, expert input, and patient-family perspectives to ensure the tool captures how CIPN affects daily activities and development. Training in survey development and implementation science will help translate findings into practice so clinicians can screen early and monitor symptoms. The effort builds on prior work showing CIPN is common and impacts development, with a focus on practical, bedside use in pediatrics.
Why it matters
Potential benefit: If successful, the survey could help clinicians identify CIPN early and tailor care to protect a child’s growth and development.
How similar studies have gone: Previous studies have identified CIPN in children and shown the value of symptom screening, but this project focuses on creating a validated, practical pediatric instrument.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Rodwin, Rozalyn — Yale University
- Study coordinator: Rodwin, Rozalyn
Related research
Other NIH-funded projects on the same topics.
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Non-invasive, microscopic biomarkers to detect CIPN in chemotherapy patients
This grant aims to develop a non-invasive imaging method to measure nerve changes in patients undergoing chemotherapy to better understand and monitor chemotherapy-induced peripheral neuropathy (CIPN).
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Longitudinal study of how body-sense relates to chemotherapy nerve damage
This study follows people with breast or gastrointestinal cancer and healthy controls to see if brain processing of body sensations contributes to chemotherapy-induced nerve damage.
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How the immune system’s CD4+ T cells in women might prevent chemotherapy-related nerve pain
A study in mice explores whether female immune cells in nerve tissue can lessen pain from chemotherapy, with potential implications for preventing CIPN in women.
-
Axonal transport and chemotherapy-related nerve pain
This grant studies why certain cancer patients develop painful nerve damage from chemotherapy and explores ways to prevent or treat it.
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Remote monitoring and nurse follow-up to manage chemotherapy-induced peripheral neuropathy
A program uses symptom reporting tools with nurse follow-up to reduce and better manage chemotherapy-induced neuropathy for cancer survivors, during and after treatment.
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Non-opioid pain relief for chemotherapy-related nerve pain using CART II
A study tests a brain-acting peptide called CART II to help reduce pain from chemotherapy-induced nerve damage without opioids.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.